Phenotyping of Chronic Pain in Diffused Systemic Scleroderma

This is a prospective, non-randomized, controlled study.

Beside the routine care, the patients will have only one visit in the study during which the informed consent will be signed, also the following will be performed: pain evaluation, blood sampling, questionnaires and Sudoscan, test QST.

100 patients will be enrolled in total with 50 in each group (scleroderma with pain vs. scleroderma without pain, 1:1 ratio), the duration of inclusion is estimated for 23 months.

2 centers will be involved in the enrollment of patients: rheumatology department and interne medicine department of Cochin hospital-APHP. One center will perform the evaluations of pain for all patients: center of pain of Cochin hospital - APHP.

Inclusion criteria

• Patients ≥ 18 years;
• Patients with diffused SSc according to ACR / EULAR Classification 2013 since at least 3 months;
• For group pain: pain intensity ≥4 of 11 points of scale (NRS);
• For group painless: pain intensity on the month before inclusion.

Exclusion criteria

• Patients unable to understand french language;
• Patients no-affiliated to the french social security scheme;
• Patients under the french AME scheme;
• Patients under guardianship;
• Pregnant and breastfeeding patients;
• Patients with thermoalgesic neuropathy;
• Articular pain from degenerative diseases (known osteoarthritis);
• Patients under antidepressant;
• Temporary discontinuation of analgesics which are not well tolerated.