Phase II Study to Evaluate the Effectiveness of EVT 302 in Smoking Cessation.

Inclusion criteria

• Smoker of at least 10 cigarettes daily
• Motivated to quit smoking
• Reports at least one unsuccessful attempt to quit in the last 2 years
• In generally good health
• Provides written informed consent to participate in the sudy

Exclusion criteria

• Pregnant or nursing females.
• Women of child-bearing potential must agree to use acceptable contraceptive precautions (contraceptive pill and one barrier method)during the study and for 2-months thereafter
• History of anaphylaxis
• History of alcohol or drug abuse
• History of or current significant medical or psychiatric disorder
• History or presence of cataract or abnormality identified by slit lamp investigation
• Use of other MAO inhibitors, pethidine, SSRIs, tricyclic antidepressants,nasal or oral decongestants or cold medicines containing ephedrine, pseudoephedrine or other sympathomimetics.
• Any medicine contraindicated for use with MAO inhibitors.
• Have or be a carrier of hepatitis B or c or HIV 1 or 2
• Use of tobacco products other than cigarettes
• Use of nicotine replacement therapy in the past month
• Received an investigational drug in the past 30 days
• Previous participation in a study with a MAO-B inhibitor