Phase 2 Study of TLK286 in Platinum Resistant Advanced Epithelial Ovarian Cancer

The purpose of this study is to determine the effectiveness and safety of TLK286 given intravenously once every week in the treatment of patients with advanced ovarian cancer that is resistant to platinum-based chemotherapy.

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Key information

Conditions

Ovarian Neoplasms Adnexal Diseases Endocrine Gland Neoplasms Endocrine System Diseases Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Genital Diseases Genital Diseases, Female Genital Neoplasms, Female Gonadal Disorders Neoplasms Neoplasms by Site Ovarian Diseases Urogenital Diseases Urogenital Neoplasms

Age range

18 year and older

Sex eligibility

Female

Study type

Interventional

Phase

Phase 2

Primary location

USC/Norris Comprehensive Cancer Center, Los Angeles, California, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Histologic diagnosis of ovarian cancer
Recurrent or persistent disease following primary therapy
Measurable disease
Prior treatment with at least one but no more than three prior chemotherapy regimens
Resistant or refractory to platinum-based chemotherapy
At least 18 years of age
Good performance status (ECOG 0 to 1)
Adequate liver, renal and bone marrow function

Exclusion criteria

Pregnant or currently breast feeding
Treatment with chemotherapy or immunotherapy within four weeks
Prior radiation to the whole pelvis

Treatment and study plan

TLK286

Drug

Sponsors and collaborators

Lead sponsor

Telik

Industry

Registry information

Important dates

Study start: 2001
Primary completion: 2005
Study completion: 2005
First posted: May 31, 2002
Registry last updated: Jul 25, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed