Phase 1 Study of SL-325 in Healthy Volunteers

Inclusion criteria

• Provide signed informed consent
• 18-55 years of age, inclusive, at the time of signing the informed consent form
• Body mass index of 18-32 kg/m2, inclusive, and a total body weight > 50 kg
• Laboratory values within normal limits or any abnormalities deemed not clinically significant by the Investigator
• Participant agrees to practice birth control measures

Exclusion criteria

• History or presence of a clinically significant infectious disease or hepatic, renal, gastrointestinal, cardiovascular, endocrine, respiratory, immunologic, hematologic, dermatologic, neurologic, or psychiatric abnormality
• Any clinically significant abnormality on vital signs, electrocardiogram (ECG), or laboratory parameters
• History of regular alcohol consumption within 6 months of Screening
• Positive test for use of drugs or alcohol at Screening
• History of use of tobacco- or nicotine-containing products within 3 months of Screening
• History of infusion-related reaction or allergic reaction upon receipt of an IV infusion
• Positive hepatitis B virus, hepatitis C virus, or human immunodeficiency virus (HIV) test at Screening
• Blood donation within 90 days prior to Day -1 or plasma donation within 1 week prior to Day 1
• Receipt of specific medications within a specified time period
• Women who are currently breastfeeding or have a positive pregnancy test