Pharmacokinetics Study of Qing'E Pill

Inclusion criteria

• Women age between 40 to 60 Years, Suffering from irregular menstrual cycle or amenorrhea of 3-11 months.
• Moderate to severe hot flashes (associated with sweating)≥5 times /24 hours.
• The score of Kupperman index is not less than 15.
• Patients unused estrogen tablets or progesterone injection in 6 months.
• Patients must discontinue other therapies in the treatment of menopausal syndrome for more than 3 months.
• Get subjects informed consent process should comply with GCP requirements.

Exclusion criteria

• There is no clinical significance abnormal in physical and laboratory examination.
• Bilateral oophorectomy, endometrial lesions, uterine polyps, abnormal vaginal bleeding, severe breast hyperplasia, with family history of breast cancer.
• Patients with hypertension, primary hypotension and chronic anemia (Hb ≤ 90 g/L).
• Patients with hyperthyroidism, coronary atheroma, diabetes, obesity (body mass index of more than 30 kg/m2), migraine, malignant tumors, thromboembolic disease, gastrointestinal diseases affect absorption or autoimmune diseases.
• Patients with diseases of the cardiovascular, cerebrovascular, liver, kidney and hematopoietic system, or mentally ill.
• People with allergies.
• People taking other drugs within 14 days before the trail.
• Patients are participating in other clinical trials within 3 months.
• Pregnant Women.
• Alcoholics or smokers (past or smoking).