Pharmacokinetics in Oral and Intranasal Formulations of Zolmitriptan.

Inclusion criteria

• Healthy male or female volunteers by physical examination, vital signs, ECG, and safety laboratory parameters and results must be within normal ranges or considered not clinically relevant by the investigator.
• Age ≥ 18 years and ≤ 55 years.
• Body mass index (BMI) ≥ 18 and ≤ 30.
• Able/willing to accept restrictions regarding diet, physical exercise, and consumption of alcohol and/or xanthine-containing items when outside the Clinical Research Unit (CRU)
• Able to read Spanish and adhere to study requirements.
• Informed consent signed before any procedure required by the study.

Exclusion criteria

• Smoking.
• History or clinically relevant diseases.
• Be under administrative or legal supervision.
• Pregnancy and breastfeeding.
• Positive blood or urine drug of abuse test or breathalyzer prior to study drug administration.
• Any history, disease, disorder, condition, anomaly or clinical finding that is relevant in the judgment of the investigator that may interfere with the study.
• Known hypersensitivity to any drug or excipient of the drug.
• Use of medications, inhibitors, any prescription or over-the-counter products, including herbs, homeopathy, vitamins, minerals, and nutritional supplements, before or during the study, that may interfere with the conduct and results of the study.
• Donation or transfusion of blood or plasma before, during or after study drug administration.
• History of inadequate venous access and/or experience of difficulty donating blood.
• Not being able/unwilling to accept restrictions regarding diet, physical exercise and consumption of alcohol and/or articles containing xanthine when outside the CRU.
• Subject included in a clinical study in the 3 months prior to the study drug administration.