Pharmacokinetic Interactions and Safety Between Exforge Tab. and Crestor Tab. in Healthy Male Subjects

Inclusion criteria

• Male volunteers in the age between 20 and 55 years old
• The weight range is not exceed ±20% of ideal weight Ideal weight = [height -100]*0.9
• Subjects with no history of any significant chronic disease
• Judged to be in good health on the basis of their electrocardiography (ECG) and routine laboratory data obtained within 3 weeks prior to study drug administration
• Willing to adhere to protocol requirements and sign a informed consent form

Exclusion criteria

• History of clinically significant allergies including drug allergies
• History of clinically significant hepatic, renal, gastrointestinal, pulmonary, ,musculoskeletal, endocrine, psychiatric, hematologic, oncologic, neurologic or cardiovascular disease
• History of genetic muscular disease and family history
• hypotension (Systolic Blood Pressure(SBP) ≤ 105 or Diastolic Blood Pressure(DBP) ≤ 65) or hypertension(SBP ≥ 150 or DBP ≥ 100)
• AST(Aspartate Transaminase), ALT(ALanine Transaminase), total bilirubin( > 1.5 times to normal range
• Creatinine clearance < 80mL/min
• Subjects with a history of gastrointestinal diseases which might significantly change ADME(Absorption, Distribution, Metabolism and Excretion) of medicines
• Serious injury, surgery and acute illness within 4 weeks prior to drug administration
• History of alcohol, smoking abuse

• alcohol > 21 units/week, 1 unit=10g=12.5mL of pure alcohol
• smoking > 10 cigarettes/day
• Use of any other medication, including herbal products, within the 2 weeks before dosing
• Participated in a previous clinical trial within 3 months prior to drug administration
• Subjects with whole blood donation within 2 months, component blood donation within months prior to drug administration
• Special diet known to interfere with the absorption, distribution, metabolism or excretion of drugs (especially, consumption of grapefruit juice) within 7 days prior to drug administration
• Clinical laboratory test values are positive (HBsAg, HCV Ab, HIV Ag/Ab, VDRL)
• Subjects considered as unsuitable based on medical judgement by investigators