Pharmacokinetic Drug Interaction Between YH4808 and Diclofenac

Inclusion criteria

• healthy male age 20 to 45 over 55kg with Ideal body weight(IBW)
• No clinically important abnormal physical findings at the screening examination
• Subject who has no congential, chronic disease and disease symptoms in medical examination result
• Subject who is judged to be eligible by principal inverstigator or sub-investigator according to various reasons includiong ther abnorminal test results(clinical laboratory test, 12-lead GCG etc)
• Ability to communicate well with the inverstigator and to comply with the requremetns of the entire study
• Willingness to give written informed consent(prior to any study-related procedures beinging performed) and to be able to adhere to the study restrictions and examination schedule

Exclusion criteria

• Suject who has history or presence of clinically significant diseases in liver, kidney, gastrointestinal tract, nervous system, respiratory system, endocrine system, blood tumor, cardiovascular, urinary system, and mental disorder
• Subject who is hypersensitive to components contained in YH4808 or declofenac or related drug(ex. rebamipide, revaprazan, NSID etc)
• Medical history of gastrointestinal disease or acid restraining surgery, gastric/ esophagus surgery(excluding appendectomy, hernia surgery)
• Subject who has history of drug dependence or using that drug
• Subject who had taken usual dose of any prescription durgs within 14 days before the treatment or who had used usual dose of OTC drugs within 7 days before the treatment
• Subject who participated in antoher clinical trial within 2 monthes before enrolling in this study
• subject who donated whole blood within 2 months or component blood within 1 month before the treatment
• Subject who drank over 21unit/week(1 unit= 10g of alcohol) or were not able to refrain from drinking alcohol during study days
• Subject who stopped smoking within 3 months before the treatment or detected cotinine in urine test
• Subject with clinically significant observations considered as unsuitable based on medical judgment by the investigators