Pharmacokinetic, Bioavailability, and Safety Study of COV155 Administered in Healthy Subjects Under Fed and Fasted Conditions

Inclusion criteria

• Males and/or non-pregnant, non-lactating or postmenopausal females, between 18 and 55 years of age with a body mass index ≥ 19 and ≤ 30 kg/m2.
• All subjects biologically capable of having children must agree and commit to the use acceptable method(s) of birth control.

Exclusion criteria

• ECG abnormalities or lab values greater than 2 times the upper limit of normal.
• Positive test results for human immunodeficiency virus (HIV), hepatitis B (HBsAg), or hepatitis C (IgG).
• Positive urine test results for drugs of abuse or history of drug/alcohol abuse.
• Use of marijuana, illicit drugs or nicotine-containing products.
• Donated or had significant loss of whole blood.
• Taken any prescription or nonprescription drugs, vitamins, minerals, or dietary/herbal supplements.
• History of abdominal and/or pelvic surgery, cholecystectomy, gastric bypass or gastric band surgery, or cardiothoracic surgery.
• History of anxiety, tension, agitation, psychiatric disorders, psychosis, or depression requiring hospitalization, psychotherapy, and/or medication.
• History of acute or chronic gastrointestinal disease or any condition that may interfere with the absorption, distribution, metabolism or excretion of the study treatment.
• History of seizures or diagnosis of epilepsy or other seizure disorder.
• History or laboratory evidence of bleeding or clotting disorder or condition.
• History or laboratory evidence of malignancy, stroke, diabetes, cardiac, renal, liver, and chronic pulmonary disease.
• Have or have a history of hay fever or seasonal allergies requiring over-the-counter or prescription medications.