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Completed

NCT Number: NCT02376595

Pharmacokinetic and Pharmacodynamic of Rocuronium

The purpose of this study is characterize the dose-effect relationship of rocuronium bromide at the adductor pollicis and masseter muscles using an pharmacokinetic-pharmacodynamic (PKPD) model. The hypothesis is that masseter muscle has a greater sensitivity to the neuromuscular blockers (rocuronium), faster onset and slower recovery profile than the adductor pollicis muscle.

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Key information

Conditions

Neuromuscular Blockade

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Scheduled for elective surgery under general anesthesia.

Exclusion criteria

  • Pregnancy.
  • Body mass index (BMI) >25 kg/m2.
  • Anticipated difficult airway.
  • Surgery associated with great volume loss.
  • Presence of any neuromuscular, hepatic, renal, cardiac or respiratory disease.
  • Previous history of neuromuscular blockade allergy, and/or administration of drugs known to interfere with neuromuscular blockade

Treatment and study plan

Rocuronium bromide

Drug

Rocuronium 0,3 mg/kg in less than five seconds, followed by a saline bolus.

Other names: Rocuronium Bromide Fresenius Kabi

Primary outcomes

  1. strength measuring 2 acceleromyograph. One Placed at the masseter muscle and the other one at the adductor pollicis muscle.

    Time frame: 60 minutes

  2. Measure blood concentrations after administration rocuronium

    Time frame: 120 minutes

Sponsors and collaborators

Lead sponsor

Pontificia Universidad Catolica de Chile

Other

Registry information

Official study title

Pharmacokinetic and Pharmacodynamic of Rocuronium Bromide Measured in Adductor Pollicis and Masseter Muscles.

Important dates

Study start
2013
Primary completion
2013
Study completion
2015
First posted
Mar 3, 2015
Registry last updated
Mar 3, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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