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NCT Number: NCT03839186

Pharmacogenetics Study on the Effects of Anesthetic Drugs on Circulatory Function

This study intends to study the effects of anesthetics on Circulatory Function Genomics and find the anesthetic effects in pharmacodynamics, pharmacokinetics, drug receptor or target DNA level differences, further guiding individual treatment in clinic, promoting the development of precision the medicine.The anesthesia medication during perioperative period is more and more accurate,reasonable and safe, so as to improve the satisfaction of the patients and their families in the perioperative period, to ensure the safety of patients.

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Key information

Conditions

Drug Reaction Anesthetic Chemically-Induced Disorders Drug-Related Side Effects and Adverse Reactions Gene Hemodynamic Rebound

Age range

20 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Xiangya Hospital of Central South University

Changsha, Hunan, 410000, China

About this study

This study is a non traumatic and non intervention study, and will use a large sample of clinical research, the number of subjects to be enrolled in the study group are 200 cases. The basic information of the study was included in the study before the operation. During the operation, the investigators need a collection of participants's arterial blood and monitor the hemodynamic index and anesthesia depth by bispectral index(BIS) . Further more，the investigators will follow up the participants' condition after operation.Dividing the patients into different groups according to their clinical features.The relationship between vital signs and the depth of anesthesia was analyzed and compared between different groups.Blood samples collected during the operation were detected by gene test. Comparing the results of genetic testing and clinical data analysis, then the investigators will find the differences in the expression of the gene polymorphisms of anesthetic drugs in the circulating function.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Undergoing general anesthesia
  • Undergoing Cardiovascular surgery

Exclusion criteria

  • ASA granding more than five
  • Severe organ dysfunction

Treatment and study plan

Primary outcomes

  1. Genotyping results of anesthetic drugs

    Time frame: one year

    Genotype information of SNP related to anesthetic drug metabolism, such as AA, AG or GG

Secondary outcomes

  1. vital signs

    Time frame: one year

    The percentage of change in mean arterial pressure and heart rate

Other outcomes

  1. depth of anesthesia

    Time frame: one year

    The value of BIS

  2. prognostic indicator

    Time frame: one year

    The days of patients' hospital stay time

Sponsors and collaborators

Lead sponsor

Xiangya Hospital of Central South University

Other

Registry information

Official study title

The Effects of Anesthetic Drugs on Hemodynamic Changes in Cardiac Surgury and the Assotiation Between Gene Polymorphysim and Different Heart Diseases :a Pharmacogenetics Study

Important dates

Study start
2016
Primary completion
2018
Study completion
2019
First posted
Feb 15, 2019
Registry last updated
Mar 2, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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