Pharmacogenetics of Propofol and Depth of Anesthesia

Propofol, (2,6-diisopropylphenol) is a short-acting anesthetic drug used for induction and maintenance of anesthesia.

The aim of this study is to evaluate plasma concentrations of propofol in relation to depth of anesthesia, measured by continuous EEG and to correlate plasma concentrations with genetic analyses of liver enzymes responsible for drug elimination.

Our hypothesis is that there is an individual requirement of Propofol plasma concentration depending on genetic differences in drug elimination.

200 patients, ASA classification 1, planned for elective surgery of a duration of at least 30 minutes will be included in this study.

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Key information

Conditions

Anesthesia Propofol

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Anesthesia and Intensive Care

Kalmar, Sweden

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Healthy caucasian patents,
(ASAclassification 1) planned for elective surgery,
with body mass index 20-30,
free from analgetic drug > 12 hours prior to anesthesia

Exclusion criteria

Pregnancy,
Smoking,
allergy to propofol or peanuts,
alcohol abuse,
non-caucasian

Treatment and study plan

Primary outcomes

EEG pattern in correlation to clinical anesthesia

Time frame: 20120101

EEG pattern in correlation to clinical anesthesia

Sponsors and collaborators

Lead sponsor

University Hospital, Linkoeping

Other

Registry information

Official study title

The Effect of Pharamocogenetices on Anesthesia Induction With Propofol

Important dates

Study start: 2010
Primary completion: 2013
Study completion: 2013
First posted: Dec 10, 2009
Registry last updated: Mar 4, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed