Pharmacodynamic Comparison of Truncal Blocks in Patients With or Without Metabolic Disease (Kidney Failure, Diabetes)

General Inclusion Criteria:

• The patient must have given his/her informed and signed consent
• The patient must be insured or beneficiary of a health insurance plan
• The patient is available for 1 month of follow up
• The patient is scheduled for hand or wrist surgery

Inclusion criteria

for the "Renal Insufficiency" group

• Patient has renal insufficiency as defined by a creatine clearance of < 30ml/min without dialysis

Inclusion criteria

for the "Diabetes" group

• Patient has chronic hyperglycemia, either a fasting glycemia > 1.26 g/l (7mmol/l) for longer than 5 years and receiving an oral, well-adjusted (last HBA1c < 6.5%)), non-insulin, antidiabetic treatment

Inclusion criteria

for the "Non-exposed" group

• Patient without metabolic or neurologic disease, with creating clearance > 90ml/min

Exclusion criteria

• The patient is participating in another study
• The patient is in an exclusion period determined by a previous study
• The patient is under judicial protection, under tutorship or curatorship
• The patient refuses to sign the consent
• It is impossible to correctly inform the patient
• The patient is pregnant
• The patient is breastfeeding
• Patient weighs less than 50 kg
• Score ASA > 4
• contra indication for locoregional anesthesia
• Severe metabolic and / or decompensated renal disease, cardiac or pulmonary decompensation
• Associated peripheral neuropathy associated with diabetes or kidney disease
• Associated central neuropathy associated (eg MS ... narrow cervical canal)
• Patients with both renal failure and diabetes