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NCT Number: NCT06974305

PET/MRI/EEG Imaging Study in Epilepsy

This study aims to better understand how epilepsy alters brain function through neuroimaging of healthy people and people with epilepsy. The study investigates how changes in brain metabolism (sugar consumption, measured by positron emission tomography [FDG-PET], and blood flow, measured by functional magnetic resonance imaging [fMRI]) relate to abnormal interictal electrical activity associated with epilepsy (measured by electroencephalography [EEG]). The study will also compare how the three imaging modalities localize regions of abnormal function in the brain.

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Key information

Conditions

Epilepsy Brain Diseases Central Nervous System Diseases Nervous System Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Athinoula A. Martinos Center

Charlestown, Massachusetts, 02129, United States

Location status: Recruiting

Location contact

Ciprian Catana

CONTACT

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18 or older

Additional Inclusion Criteria for Subjects with Epilepsy:

  • Diagnosed with epilepsy with abnormal interictal EEG

Exclusion criteria

  • Contraindications to PET, MRI, or EEG imaging
  • History of severe brain disease such as stroke and head trauma
  • History of brain surgery
  • History of type I or II diabetes mellitus
  • Fasting plasma glucose level >200 mg/dL
  • Employed under direct supervision of the PI conducting the research

Additional Exclusion Criteria for Healthy Subjects:

  • Current use of drugs that modulate brain function
  • Current or past history of major medical, neurological, or psychiatric conditions

Treatment and study plan

FDG-PET/fMRI/EEG imaging

Radiation

Subject will undergo simultaneous EEG, fMRI, and FDG-PET imaging. This includes the use of a standard injected radioactive marker used in PET imaging.

Primary outcomes

  1. Image analysis

    Time frame: Image analysis to be performed after imaging sessions are complete.

    There are no interventions in this study and thus no outcome measures. Primary goal of the study will be achieved with image analysis on the PET/MRI/EEG data.

Study contacts

Contact information is provided by the study sponsor or research team.

Magdelena S Allen, BA

CONTACT

[email protected]

617-724-9232

Sponsors and collaborators

Lead sponsor

Massachusetts General Hospital

Other

Registry information

Official study title

Investigation of Interictal Metabolic and Electrophysiologic Changes in Epilepsy Through Trimodal Neuroimaging

Important dates

Study start
2023
Primary completion
2026
Study completion
2026
First posted
May 15, 2025
Registry last updated
Apr 23, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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