Skip to main content
OpenTrials
Active, Not Recruiting

NCT Number: NCT04571177

PET Perfusion Imaging Techniques and Comparing Them to CT Perfusion Imaging in Stroke

Adult patients who are diagnosed with an acute supratentorial ischemic stroke within 48 hrs of onset will be enrolled into the study. Participants will undergo both a CT Scan and PET scan within 7 days of onset. Participants will have the option to undergo a second PET scan with fluorodeoxyglucose (FDG).

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Acute Ischemic Stroke Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Ischemic Stroke Nervous System Diseases Stroke Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Alberta

Edmonton, Alberta, T6G2B7, Canada

About this study

Patients older than 18 years of age diagnosed with an acute supratentorial ischemic stroke within 48 hrs of symptom onset will be prospectively enrolled. Research imaging will be obtained before 7 days after symptom onset. The patient will receive the standardized treatment protocol at the hospital. Informed consent will be obtained from each patient or a substitute decision maker for each individual imaging study (CTP, Rb PET, and FDG PET). The patient will be given the option of undergoing the CTP imaging with the Rb PET only or both the Rb PET and FDG PET components.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age: >18 yo
  • Gender: male or female
  • Acute (within 7 days from symptom onset) Supratentorial Ischemic Stroke

Exclusion criteria

  • 1) Planned surgical intervention
  • 2) Severely abnormal blood glucose level (will be excluded from FDG PET imaging)
  • 3) Unable to undergo CTP or PET imaging (i.e. claustrophobia)
  • 4) Pregnancy

Treatment and study plan

Primary outcomes

  1. Compare PET brain perfusion imaging to CTP

    Time frame: through study completion, 1 year from start of recruitment

    Imaging of CTP images with the Rb PET only or both the Rb PET and FDG PET with CTP imaging components to evaluate blood flow and metabolism mismatches.

Sponsors and collaborators

Lead sponsor

University of Alberta

Other

Registry information

Official study title

Developing PET Perfusion Imaging Techniques and Comparing Them to CT Perfusion Imaging in Stroke Patients

Important dates

Study start
2016
Primary completion
2028
Study completion
2028
First posted
Sep 30, 2020
Registry last updated
Apr 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.