Peking Union Medical College Hospital
Beijing, Beijing Municipality, 100730, China
NCT Number: NCT05307913
This study is a multicentric randomized controlled study.The objective of this study is to compare the prognosis of patients with ARDS between EIT-oriented individualized PEEP and traditional lower PEEP/FiO2 table-oriented PEEP strategy.
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Notify Me18 year–90 year
All sexes
Interventional
Not applicable
Beijing, Beijing Municipality, 100730, China
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Intubated, mechanically ventilated patients with diagnosis of ARDS according to ARDS Berlin standard by attending doctor
Exclusion criteria
PEEP setting according to EIT
PEEP setting according to the lower PEEP/FiO2 table
Time frame: 28 days
Survival within 28 days from randomization
Time frame: Maximum 6-months
Length of hospital stay from randomization to ICU discharge
Time frame: Maximum 6-months
Length of hospital stay from randomization to hospital discharge
Time frame: 28 days
Number of days alive and out of mechanical ventilation between randomization and 28 days after randomization.
Time frame: 7 days
We consider as barotrauma within 7 days any pneumothorax, pneumomediastinum, subcutaneous emphysema or pneumatocele > 2cm detected on image exams between randomization and 7 days, except those judged to be clearly caused by invasive procedures.
Time frame: Maximum 6-months
Survival at ICU discharge.
Time frame: Maximum 6-months
Survival at hospital discharge.
Time frame: 2 days
change of SOFA score within first 2 days
Peking Union Medical College Hospital
Other
EIT-guided PEEP Titration Versus Low PEEP/FiO2 Table for ARDS: a Multicenter, Randomized, Controlled Trial
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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