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Completed

NCT Number: NCT00846339

PET Imaging Study on Occupancy of Dopamine D2 Receptors and Genotypes After Bupropion Administration

Bupropion has different effects on D2 dopamine receptors according to genotype.

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Key information

Conditions

Smoking Behavior Health Behavior Smoking Cessation

Age range

20 year–50 year

Sex eligibility

Male

Study type

Interventional

Phase

Phase 4

Primary location

Seoul National University Hospital

Seoul, 110-744, South Korea

About this study

Open, one arm, single sequence, 2-period, study stratified into 2 DRD2 genotype groups For subjects who volunteer to cease smoking, genotypes are investigated. Twelve subjects are enrolled (6 - DRD2 Taq1A1 allele, 6 - DRD2 Taq1A2 homozygotes). Subjects receive baseline raclopride PET (High Specific Activity, Low Specific Activity).

  • Period 1 Subjects receive 150 mg of bupropion SR every day. After 1 week of medication, pharmacokinetic and PET studies are performed.
  • Period 2 Subjects receive 150 mg of bupropion SR twice a day. After 1 week of medication, pharmacokinetic and PET studies are performed.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Active smoker (more than 10 cigarettes per day for the past 2 years)

Exclusion criteria

  • Medical or psychiatric co-morbidity
  • Hypersensitive to bupropion

Treatment and study plan

bupropion

Drug

bupropion

Primary outcomes

  1. Dopamine receptor occupancy

    Time frame: 1 week

Secondary outcomes

  1. Pharmacokinetic parameters of bupropion and hydroxybupropion

    Time frame: 1 week

Sponsors and collaborators

Lead sponsor

Seoul National University Hospital

Other

Collaborators

  • Korea National Enterprise for Clinical Trials
  • Ministry of Health, Welfare and Family Affairs

Registry information

Official study title

[11C] Raclopride PET Imaging Study That Investigates Relation Between Occupancy of Dopamine D2 Receptors and Genotypes of DRD2 After Bupropion Administration

Important dates

Study start
2008
Primary completion
2009
Study completion
2009
First posted
Feb 18, 2009
Registry last updated
Feb 23, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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