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NCT Number: NCT06162988

PET Imaging of 68Ga-NOTA-H006 in Malignancy

5T4, also known as trophoblast glycoprotein, is an oncofoetal antigen expressing in fetal development and cancer but rarely in adult. The high expression of 5T4 in malignancy was found be associated with poor clinical outcomes in ovarian, gastric and colorectal cancers. Several antibody drug conjugates are currently under development for cancer therapy in preclinic and clinic stages.

Previously, investigators engineered a 5T4-specific biomolecule with nanomolar binding affinity. Radiolabeling with gallium-68 resulted in 68Ga-NOTA-H006 which showed 5T4 expression in a variety of xenograft models. Thus, the aims of current study are to evaluate the distribution and dosimetry of this novel tracer, and to explore the diagnostic values of 68Ga-NOTA-H006 in malignant tumors.

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Key information

Conditions

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Pancreatic cancer clinical trial study subjects must meet all of the following criteria:
  • Age between 18 and 65 years old.
  • Pancreatic occupancy is found on imaging and combined with clinical judgment as a patient with pancreatic cancer.
  • Written informed consent signed by the subject or his/her legal guardian or caregiver.
  • Willingness and ability to cooperate with all programs of the study.

Lung cancer clinical trial study subjects must meet all of the following criteria:

  • Be between the ages of 18 and 65 years old.
  • Patients with CT findings of suspicious space on the lungs with a diameter of more than 1cm who have not undergone surgery.
  • Written informed consent must be signed by the subject or his/her legal guardian or caregiver.
  • Willingness and ability to cooperate with all programs of the study.

Bowel cancer clinical trial study subjects must meet all of the following criteria:

  • Be between the ages of 18 and 65.
  • Have a clear histologic or pathologic diagnosis of colorectal cancer.
  • Written informed consent signed by the subject or legal guardian or caregiver.
  • Willingness and ability to cooperate with all programs of this study.

Exclusion criteria

  • Severe hepatic or renal insufficiency;
  • Targeted therapy prior to radiotherapy or PET/CT scan. 5T4 expression in existing lesions assessed by immunohistochemistry using antibody clones.
  • History of serious surgery in the last month.
  • Those who have participated in other clinical trials during the same period.

Treatment and study plan

68Ga-NOTA-H006 is injected intravenously with a dose of 1.8 MBq[0.05MCi]/kg.

Drug

68Ga-NOTA-H006:PET imaging; 18F-FDG:PET imaging

Primary outcomes

  1. Establishment and optimization of imaging method for 68Ga-NOTA-H006 PET

    Time frame: 90mins from time of injection

    Analyze the standardized uptake value (SUV) of 68Ga-NOTA-H006 on the lesions Compare the SUV with 5T4 expression in pathological specimens

Study contacts

Contact information is provided by the study sponsor or research team.

Yihui Guan, MD

CONTACT

[email protected]

13764308300 ext. +86

Sponsors and collaborators

Lead sponsor

YiHui Guan

Other

Registry information

Official study title

A Study to Evaluate 5T4 Expression in Malignant Tumors Using 68Ga-NOTA-H006

Important dates

Study start
2023
Primary completion
2024
Study completion
2028
First posted
Dec 8, 2023
Registry last updated
Dec 8, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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