Huashan Hospital
Shanghai, 200040, China
NCT Number: NCT06162988
5T4, also known as trophoblast glycoprotein, is an oncofoetal antigen expressing in fetal development and cancer but rarely in adult. The high expression of 5T4 in malignancy was found be associated with poor clinical outcomes in ovarian, gastric and colorectal cancers. Several antibody drug conjugates are currently under development for cancer therapy in preclinic and clinic stages.
Previously, investigators engineered a 5T4-specific biomolecule with nanomolar binding affinity. Radiolabeling with gallium-68 resulted in 68Ga-NOTA-H006 which showed 5T4 expression in a variety of xenograft models. Thus, the aims of current study are to evaluate the distribution and dosimetry of this novel tracer, and to explore the diagnostic values of 68Ga-NOTA-H006 in malignant tumors.
Trial opening soon.
Get Notified18 year–65 year
All sexes
Interventional
Not applicable
Shanghai, 200040, China
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Lung cancer clinical trial study subjects must meet all of the following criteria:
Bowel cancer clinical trial study subjects must meet all of the following criteria:
Exclusion criteria
68Ga-NOTA-H006:PET imaging; 18F-FDG:PET imaging
Time frame: 90mins from time of injection
Analyze the standardized uptake value (SUV) of 68Ga-NOTA-H006 on the lesions Compare the SUV with 5T4 expression in pathological specimens
Contact information is provided by the study sponsor or research team.
YiHui Guan
Other
A Study to Evaluate 5T4 Expression in Malignant Tumors Using 68Ga-NOTA-H006
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