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Completed

NCT Number: NCT03191643

PET-guided External Beam Radiotherapy in Differentiated Thyroid Cancer

Description of the role of a post-operative external beam radiotherapy in patients with differentiated thyroid cancer.

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Key information

Conditions

Differentiated Thyroid Cancer

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

About this study

The role of post-operative external beam radiotherapy (EBRT) in differentiated thyroid cancer is still discussed considering the low clinical aggressiveness and the availability of ablative 131Iodine therapy. However, there is a subgroup of tumors which lose the ability to capture Iodine over time. This study wants to describe the role of a post-operative external beam radiotherapy in patients with differentiated thyroid cancer.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • detectable thyroglobulin (Tg),
  • negative post-metabolic radiotherapy whole body scintigraphy,
  • no surgical indications.

Exclusion criteria

  • prior radiotherapy in the head and neck area
  • pregnancy

Treatment and study plan

Primary outcomes

  1. Progression free survival (PFS)

    Time frame: 6 months

    Progression-free survival (PFS) after radiotherapy is evaluated with CT-scan and 18F FDG PET-scan. Also laboratory tests are performed (HTG serum level evaluation in case of biochemical recurrence).

Secondary outcomes

  1. toxicities

    Time frame: 6 months

    Acute and late toxicities after radiotherapy are assessed with CTCAE v. 4.03 and EORTC-RTOG scales, respectively.

Sponsors and collaborators

Lead sponsor

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Other

Registry information

Official study title

18F-FDG PET-guided External Beam Radiotherapy in Iodine-refractory Differentiated Thyroid Cancer

Important dates

Study start
2011
Primary completion
2016
Study completion
2016
First posted
Jun 19, 2017
Registry last updated
Jun 19, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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