PET-CT to Assess Brain Damage in Cardiac Arrest Patients

This was a single-center, observational study. Patients with successful cardiopulmonary resuscitation (CPR) will be transferred to the emergency intensive care unit for further standardized management. After successful return of spontaneous circulation (ROSC) for 72 hours and hemodynamic stability for 24 hours, the patients underwent positron emission computed tomography (PET-CT) examination after resuscitation. The supervising physician accompanied the patient and used monitors to monitor vital signs during the examination. Patients who were on ventilators were mechanically ventilated with a magnetic ventilator (HAMILTON-MRI, United States). In addition to conventional cerebral oxygen metabolism, cerebral blood flow, oxygen extraction fraction, cerebral blood volume and other indicators were added in this experiment. These indicators can evaluate the patient's cerebral metabolism, cerebral blood flow and cerebral blood oxygen damage degree. The neurological outcome was followed up 6 months after onset according to the cerebral performance category（CPC）.

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Key information

Conditions

Cardiac Arrest Brain Diseases Brain Injuries Cardiovascular Diseases Central Nervous System Diseases Craniocerebral Trauma Heart Arrest Heart Diseases Nervous System Diseases Trauma, Nervous System Wounds and Injuries

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Beijing chaoyang hospital

Beijing, Beijing Municipality, 100020, China

Location contact

Weijie Cheng, M.D

CONTACT

[email protected]

+86 18980360089

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

age ≥18 years.
sustained hemodynamic stability for ≥24h.
the patients were unconscious and not able to obey verbal commands. • Advanced life support and target temperature management within 6 hours of return of spontaneous circulation (ROSC).

Exclusion criteria

Patients with hemodynamic instability.
Patients who could not complete cranial PET-CT examination for special reasons. • Patients during pregnancy.
Patients who combined traumatic brain injury, stroke, cerebral hemorrhage and other diseases.
Patients whose family members did not agree to be enrolled.

Treatment and study plan

No interventions

Other

No interventions

Primary outcomes

Neurologic prognosis

Time frame: 6 months

Patients will be followed up for neurologic prognosis according to the Cerebral Performance Category Scale（CPC）at 6 months after disease onset.The CPC score was divided into five grades. Grade 1 represented intact brain function, the patient was awake and alert, and had the ability to live and work normally. Grade 2 represents moderate cerebral disability, in which the person is awake and able to work part of the time in a specific environment or perform daily activities independently; Grade 3, severe cerebral disability: the person is awake but dependent on others for daily assistance and retains limited cognition; Grade 4 represents coma and vegetative state, the patient is unconscious, unconscious to the environment, and has no cognitive ability; Level 5 represents death, with the patient confirmed as brain death or death by traditional criteria. According to the CPC score, grade 1-2 was defined as good neurological outcome, and grade 3-5 was defined as poor neurological outcome.

Study contacts

Contact information is provided by the study sponsor or research team.

Ziren Tang

CONTACT

[email protected]

+86 010-85231530

Sponsors and collaborators

Lead sponsor

Capital Medical University

Other

Registry information

Official study title

Assessment of Cerebral Metabolism, Cerebral Blood Flow and Cerebral Oxygen Damage in Patients With Cardiac Arrest Using PET-CT

Important dates

Study start: 2025
Primary completion: 2027
Study completion: 2027
First posted: Oct 28, 2024
Registry last updated: Apr 11, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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