PET and MRI Imaging of Brain Tumors Using [18F]PARPi

This study is to collect data about how 18FPARPi can be used together with PET/positron emission tomography and MRI/magnetic resonance imaging scans to take pictures of brain cancer

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Key information

Conditions

Brain Tumor Brain Cancer Brain Diseases Brain Neoplasms Central Nervous System Diseases Central Nervous System Neoplasms Neoplasms Neoplasms by Site Nervous System Diseases Nervous System Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Early Phase 1

Primary location

Memorial Sloan Kettering Cancer Center

New York, 10065, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients with new or suspected recurrent brain tumors (including suspected recurrent brain tumors showing growth from any preceding scan)
Age >/= 18 years
Minimum at least one brain lesion size >/= 1.5cm diameter
Scheduled to undergo treatment at MSK
Willingness to sign informed consent
Able to receive intravenous gadolinium contrast per MSK Department of Radiology guidelines

Exclusion criteria

Any contraindication to 3T MRI (PET/MR scanner is 4.0 Tesla)
Pregnancy or breast-feeding women

Treatment and study plan

PET/MR with [18F]PARPi

Diagnostic Test

One PET/MR study (with up to 3 scan times) with [18F]PARPi

[18F]PARPi

Drug

Injection of <100ug of [18F]PARPi prior to 1 PET/MR

Primary outcomes

SUVmax measurements

Time frame: Up to 24 weeks

[18F]PARPi updtake in lesions will be quantified by standard SUVmax measurements from PET/MR scans

Sponsors and collaborators

Lead sponsor

Memorial Sloan Kettering Cancer Center

Other

Registry information

Official study title

Pilot Study of [18F]PARPi PET/MR Imaging in Patients With New and/or Suspected Recurrent Brain Tumors

Important dates

Study start: 2019
Primary completion: 2026
Study completion: 2026
First posted: Nov 21, 2019
Registry last updated: Feb 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed