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Recruiting

NCT Number: NCT06420310

Pesticides and Parkinson´s Disease

The aim of this project is to study whether people exposed to pesticides have a higher risk of developing PD. We will perform an epidemiological study determining the presence of pesticides in urine and comparing signs traditionally associated with PD in early forms.

Recruiting

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Key information

Conditions

Pesticide-Induced Parkinsonism

Age range

45 year–55 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Hospital Universitario de Burgos

Burgos, 09006, Spain

Location status: Recruiting

Location contact

Esther Cubo, MD

CONTACT

[email protected]

+34947256533

About this study

Within different risk factors, pesticide exposure increases the risk of developing Parkinson's disease (PD) through epigenetic mechanisms by modifying the expression of genes related to PD and secondary mitochondrial dysfunction.We will conduct a cross-sectional prevalence study with cases (exposed to pesticides) and controls (not exposed to pesticides), randomly selecting 130 individuals in each group. Pesticide exposure will be determined through questionnaires.We will study the prevalence of preclinical and prodromal PD based on pesticide exposure, stratified by age and gender in the exposed, and non-exposed groups. Preclinical and prodromal PD will be assessed using: biological biomarkers and prodromal PD signs. Multivariate analyses will be employed to determine the risk of presenting early PD, adjusting for different clinical covariates. The results of this study will allow us to understand the early mechanisms associated with neurodegeneration and pesticides exposure.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Farmers exposed to pesticides for cases
  • No work exposure to pesticides for controls

Exclusion criteria

  • Subjects without signed consent form
  • Neurological significant conditions

Treatment and study plan

exposure to pesticides

Other

based on work exposures to pesticides

Primary outcomes

  1. Prodromal PD

    Time frame: over the last year

    Early non motor symptoms

Sponsors and collaborators

Lead sponsor

Hospital Universitario de Burgos

Other

Registry information

Official study title

Prevalence of Preclinical and Prodromal Parkinson´s Disease in Subjects Exposed to Pesticides

Acronym: Pest-PD

Important dates

Study start
2024
Primary completion
2028
Study completion
2028
First posted
May 20, 2024
Registry last updated
May 20, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.