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NCT Number: NCT07653841

Perturbation Based Balance Training Versus Progressive Neuromuscular Training as an Adjunct to Conventional Physiotherapy for Pain Reduction and Functional Improvement in Knee Osteoarthritis

This is an RCT aims to explore Perturbation-Based Balance Training versus Progressive Neuromuscular Training as an Adjunct to Conventional Physiotherapy for Pain Reduction and Functional Improvement in Knee Osteoarthritis.

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Key information

Conditions

Knee Arthritis Osteoarthritis Arthritis Joint Diseases Knee Arthritis, Osteoarthritis Musculoskeletal Diseases Osteoarthritis Rheumatic Diseases

Age range

40 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Institute of Medical Rehabilitation (IMR)

Islamabad, ICT, Pakistan

Location status: Recruiting

Location contact

Rashid Nawaz, DPT, MSPT MSK

CONTACT

[email protected]

+923160534195

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Male and female, aged between 40-70 years Diagnosed with knee osteoarthritis Grades I-III based on the Kellgren-Lawrence classification Chronic knee pain for ≥3 months Ability to walk independently

Exclusion criteria

Grade IV osteoarthritis Previous knee surgery or joint replacement Rheumatoid arthritis or inflammatory joint disease Recent intra-articular injection (<6 months) Severe systemic illness, Neurological disorders and Vestibular disorders

Treatment and study plan

Perturbation-based balance training

Other

3 sessions/week 20-25 min (2 sets × 30 sec/activity) Starts with Low-Moderate (slow, predictable external perturbations) progress to Moderate-High (fast, unpredictable perturbations) 30-35 min (3 sets × 45-60 sec)

Other names: (PBBT)

Progressive Neuromuscular Training

Other

3 sessions/week 20-25 min (2 sets × 10-12 reps) starts with Low-Moderate (RPE 9-11) then proceeds to Moderate (RPE 11-13)

Other names: (NMT)

Primary outcomes

  1. Pain & Functional Ability

    Time frame: Baseline to Week 6

    Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)

Secondary outcomes

  1. Functional Mobility

    Time frame: Baseline to Week 6

    Functional Mobility will be measured using Time Up & Go test

  2. Muscle strength

    Time frame: Baseline to week 6

    Handheld Dynamometer

  3. Balance

    Time frame: Baseline to week 6

    Functional Reach Test

Study contacts

Contact information is provided by the study sponsor or research team.

Rashid Nawaz, DPT, MSPT MSK

CONTACT

[email protected]

+923160534195

Sidra Hanif, DPT, MSNMPT, PhD PT

CONTACT

[email protected]

+923335985631

Sponsors and collaborators

Lead sponsor

Ibadat International University, Islamabad

Other

Registry information

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Jun 17, 2026
Registry last updated
Jun 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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