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OpenTrials
Completed

NCT Number: NCT04840121

Personalizing Window of Implantation During Frozen Embryo Transfer

Embryo implantation is a crucial event in the establishment of a pregnancy. Although the clinical and culture conditions to obtain a "good quality" embryo are well advanced today, endometrial receptivity remains a major barrier in assisted reproductive techniques. Once a high-quality embryo is transferred, impaired uterine receptivity is believed to be one of the major reasons behind failure of the establishment of pregnancy.

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Key information

Conditions

Fertility

Age range

18 year–40 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Clinique Ovo

Montreal, Quebec, H4P 2S4, Canada

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Women between the ages of 18 to 40 inclusive at the time of oocyte retrieval
  • Prescription of a single frozen embryo transfer - substituted cycle protocol
  • Participant has at least 2 vitrified good quality blastocysts

Exclusion criteria

  • Women undergoing fertility preservation
  • Stage IV severe endometriosis
  • Severe malformation, adenomyosis or uterine anomaly including fibroids deforming the uterine cavity ≥ 5 cm
  • Positive results of screening for either participant or partner for HIV antibodies, Hepatitis B (other than surface antibodies present after vaccination) or Hepatitis C

Treatment and study plan

AdhesioRT

Diagnostic Test

AdhesioRT, a novel diagnostic genetic assay, developed by ovo R&D scientists, helps to predict the endometrial receptivity and embryo implantation.

Primary outcomes

  1. Determination of appropriate window of implantation

    Time frame: 14 days after embryo transfer

    Comparison between standard frozen embryo transfer and personalized frozen embryo transfer using AdhesioRT to determine a successful window of implantation

Secondary outcomes

  1. Rate of clinical pregnancy

    Time frame: 14 days after embryo transfer

    Blood test to determine if the embryo transfer was successful or not

Sponsors and collaborators

Lead sponsor

Clinique Ovo

Industry

Collaborators

  • Ferring Pharmaceuticals

Registry information

Official study title

ADHESIORT - Personalizing Window of Implantation During Frozen Embryo Transfer

Acronym: AdhesioRT

Important dates

Study start
2021
Primary completion
2023
Study completion
2024
First posted
Apr 9, 2021
Registry last updated
Feb 20, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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