Personalized Ultrasonic Brain Stimulation for Depression

Inclusion criteria

• Age 18-65, any gender
• Primary diagnosis of major depressive disorder or bipolar disorder
• Current moderate-to-severe depressive episode, without psychotic features, lasting at least 2 months
• Self-rated 16-item Quick Inventory of Depressive Symptomatology (QIDS) total score > 10
• Stated willingness to comply with all study procedures and avoid changes to psychiatric treatments (medications, psychotherapy) for the duration of the study
• For females of reproductive potential: negative pregnancy test or use of highly effective contraception for at least 1 month prior to baseline; agreement to use such a method throughout the study
• Capacity to provide informed consent; provision of a signed and dated consent form

Exclusion criteria

• History of serious brain injury or other neurologic disorder
• Poorly managed general medical condition
• Pregnant or breast feeding
• Implanted device in the head or neck
• MRI intolerance or contraindication
• Brain stimulation (e.g., ECT, TMS, VNS) in the past month
• Suicidal ideation (Columbia Suicide Severity Rating Scale screen item #2, past month)
• Lifetime history of a serious suicide attempt
• Moderate-to-severe substance use disorder (past 3 months)
• Obsessive compulsive disorder (past month)
• Posttraumatic stress disorder (past month)
• Schizophrenia-spectrum disorder (lifetime)
• Neurocognitive disorder (past year)
• Personality disorder as a current focus of treatment
• Clinically inappropriate for participation in the study as determined by the study team