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Completed

NCT Number: NCT03971864

Peripheral Vascular Disease and Coronary Artery Disease

This study aims at evaluating the relationship between peripheral artery plaque characteristics evaluated by ultrasound and coronary culprit lesion characteristics evaluated by OCT in ACS patients.

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Key information

Conditions

Acute Coronary Syndrome Cardiovascular Diseases Heart Diseases Myocardial Ischemia Vascular Diseases

Age range

18 year–85 year

Sex eligibility

All sexes

Study type

Observational

Primary location

The Second Affiliated Hospital of Harbin Medical University

Harbin, Heilongjiang, 150081, China

About this study

Patients with acute coronary syndrome (ACS) who underwent percutaneous coronary intervention (PCI) and optical coherence tomography (OCT) are included in this study. Two skillful echocardiographers will evaluate peripheral artery plaque characteristics by ultrasound.Ultrasound parameters of peripheral artery will be compared among patients with different coronary culprit lesion characteristics, such as plaque rupture and plaque erosion.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosed as ACS underwent coronary angiography and OCT examination
  • Agreed to accept peripheral artery ultrasound examination

Exclusion criteria

  • In-stent restenosis, coronary dissection, coronary spam, thrombus
  • left main artery disease
  • Age>85 years old
  • Cardiogenic shock or stroke admission
  • Severe hepatic or renal dysfunction
  • Poor quality of OCT image or massive thrombus

Treatment and study plan

Primary outcomes

  1. Differences in ultrasound parameters of peripheral artery plaque according to different coronary culprit lesion morphology.

    Time frame: Baseline

    Plaque rupture is characterized by the presence of fibrous cap discontinuity with a cavity formation. plaque erosion is characterized by the presence of the attached thrombus overlying an intact and visual plaque, luminal surface irregularity at the culprit lesion in the absence of thrombus, or attenuation of the underlying plaque by thrombus without superficial lipid or calcification immediately proximal or distal to the site of thrombus.Patients with plaque erosion have less plaques, lower intima-media thickness (IMT), lower plaque score (PS) compared to patients with plaque rupture.

Sponsors and collaborators

Lead sponsor

Harbin Medical University

Other

Registry information

Official study title

The Relationship Between Peripheral Artery Plaque Characteristics Evaluated by Ultrasound and Coronary Culprit Lesion Characteristics Evaluated by OCT in ACS Patients

Important dates

Study start
2018
Primary completion
2019
Study completion
2019
First posted
Jun 3, 2019
Registry last updated
Sep 16, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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