Institute for Human Centered Engineering HuCE
Biel, 2502, Switzerland
Location status: Recruiting
Recruiting
NCT Number: NCT07160413
Peripheral Nerve Activation Sensitivity
Volunteers will undergo various peripheral nerve stimulations (electric, electromagnetic, and temporal interference) to evaluate each method's sensitivity. The main objective is to examine the relationship between nerve activation and coil placement relative to the nerve, as well as how different coil types influence maximal nerve activation.
Recruiting
Interested in participating?
Request InfoKey information
Conditions
Age range
18 year and older
Sex eligibility
All sexes
Study type
Interventional
Phase
Not applicable
Primary location
Who can participate
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- Person aged > 18 years
- Signed informed consent
- Healthy
- Willingness and ability to adhere to study procedures
Exclusion criteria
- Known hypersensitivity to electric or electromagnetic stimulation
- Any implanted metal or electronic device in the upper body (except dental work such as fillings or braces), e.g., active medical devices, metal implants
- Neurological or neuromuscular disorders or conditions
- History of seizures or epilepsy
- Current treatment with drugs that lower seizure threshold (e.g., certain analgesics, methylxanthines, antipsychotics, antidepressants, antiepileptics, anesthetics)
- Pregnancy or breastfeeding
- Surgical intervention of the arm within the last 4 weeks
- Allergy to adhesives or ultrasound gel components (e.g., polyethylene glycols)
- Skin lesions, infections, or strictures in the arm region
- Tattoos on the stimulated (right) arm and hand, or in any area likely to be captured in video recordings
- Inability to follow study procedures (e.g., due to language barrier, psychological disorders, dementia)
- Participant deprived of liberty by administrative or judicial decision or under legal guardianship
Treatment and study plan
Electric and electromagnetic stimulation
DeviceApplication of electromagnetic and electric stimulation using coils of different designs and electrodes to assess peripheral nerve sensitivity. The stimulation is momentary, non-therapeutic, and performed for basic science research purposes
Primary outcomes
-
Maximum nerve activation response to electromagnetic stimulation with different coils
Time frame: Day 1
Maximum of the measured signals (muscle contraction from electromyography (EMG) and finger movement from accelerometer) obtained across all stimulation positions at a given stimulation intensity for each coil type. This reflects the relative sensitivity of peripheral nerves to electromagnetic stimulation with different coil designs.
Secondary outcomes
-
Spatial range of nerve activation with electromagnetic coils
Time frame: Day 1
Distance around the stimulation position yielding the maximum response (E1), within which the measured signals (muscle contraction and finger movement) remain at least 50% of the maximum, across all coil positions at a given stimulation intensity.
-
Spatial range of nerve activation with neuromuscular electrical stimulation electrodes (NMES)
Time frame: Day 1
Distance around the stimulation position yielding the maximum response, within which the measured signals (muscle contraction and finger movement) remain at least 50% of the maximum, across all NMES electrode positions at a given stimulation intensity.
-
Amplitude ratios of temporal interference stimulation (TIS) electrodes associated with nerve activation
Time frame: Day 1
Electrode amplitude ratios during Temporal Interference Stimulation (TIS) for which measured signals remain at least 50% of the maximum signals observed at the optimal position.
Study contacts
Contact information is provided by the study sponsor or research team.
Sponsors and collaborators
Lead sponsor
Thomas Niederhauser
Other
Collaborators
- Bern University of Applied Sciences
- Swiss Paraplegic Research, Nottwil
Registry information
Official study title
Peripheral Nerve Activation Sensitivity to Electromagnetic and Electrical Stimulation in the Upper Arm
Acronym: PERNEAC
Important dates
- Study start
- 2025
- Primary completion
- 2025
- Study completion
- 2026
- First posted
- Sep 8, 2025
- Registry last updated
- Sep 12, 2025
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.