Periostin and Non-Surgical Periodontal Treatment

A total of 90 subjects, 30 patients with chronic periodontitis, 30 with gingivitis and 30 periodontally healthy subjects were included. Patients with periodontal disease received non-surgical periodontal treatment. Gingival crevicular fluid periostin levels were assessed at baseline, at the 6th week and the 3rd month after treatment.

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Key information

Conditions

Periodontal Diseases Chronic Disease Chronic Periodontitis Disease Attributes Gingival Diseases Gingivitis Infections Mouth Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Periodontitis Stomatognathic Diseases

Age range

20 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Periostin is commonly found in collagen-rich tissues, which is thought to affect the production of collagen fibers. Additionally, periostin is synthesized in tissues exposed to constant mechanical forces such as the periosteum, periodontal ligament, tendon, heart valve and skin. Periostin mediates inflammation and fibrosis during diseases of various organs, including the heart, lung, kidney, skin, liver, skeletal muscle and retina.

This study evaluated periostin levels in gingival crevicular fluid from patients with chronic periodontitis, gingivitis and periodontally healthy as well as the effect of non-surgical periodontal treatment on gingival crevicular fluid periostin levels.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Clinical diagnosis of chronic periodontitis
Clinical diagnosis of gingivitis
Clinical diagnosis of periodontal health

Exclusion criteria

have any systemic disease
to be alcohol consumer
to receive any periodontal therapy in the past 6 months
to take any drugs regularly
to be pregnant and/or lactate

Treatment and study plan

Non-surgical periodontal treatment

Procedure

Scaling and root planing and polishing with specific curettes were performed to patients and oral hygiene education was provided to each patient.

Other names: Initial periodontal therapy

Primary outcomes

Change in periostin

Time frame: Baseline, 6th week and 3rd month

Total amount of Periostin (pg/30 sec) in gingival crevicular fluid

Secondary outcomes

Change in periodontal clinical parameter

Time frame: Baseline, 6th week and 3rd month

Clinical attachment level (mm) (from cemento-enamel junction to the base of periodontal pocket)

Sponsors and collaborators

Lead sponsor

Kırıkkale University

Other

Registry information

Official study title

The Effect of Non-Surgical Periodontal Treatment on Gingival Crevicular Fluid Periostin Levels in Patients With Gingivitis and Chronic Periodontitis

Important dates

Study start: 2017
Primary completion: 2018
Study completion: 2018
First posted: Apr 3, 2020
Registry last updated: Apr 3, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed