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NCT Number: NCT07582445

Perioperative Prospective Follow Up Of Cannabis Consumers and Discrepancy Use

This study includes a prospective non interventional study that aims to asses the prevalence of cannabis use among patients undergoing elective surgery and evaluates its impact on perioperative outcomes, including pain, opioid consumption, nausea, anxiety, and sleep disturbances. A matched control cohort will provide comparative data. Discrepancies between self-reported and objectively measured cannabis use will be assessed using blood samples and urine samples. Participants will be requested to complete preoperative and postoperative questionnaires on days 1, 2, 3, 7, and 30 to monitor cannabis use and perioperative symptoms. This study aims to clarify the perioperative effects of cannabis use and the accuracy of patient-reported consumption.

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Key information

Conditions

Cannabinoid Discrepancy With Clinical Examination

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Hadassah Medical Center

Jerusalem, 9210141, Israel

About this study

This study aims to assess the proportion of cannabis users who undergo surgery. In addition, we seek to evaluate whether chronic cannabis use affects the perioperative period. Specifically, we will examine whether cannabis use around the time of surgery influences levels of pain, opioid consumption, nausea, anxiety, and sleep disturbances.

A matched control cohort with similar patient characteristics will be used for comparison.

Another key objective is to assess discrepancies between patients' self-reported cannabis use and their actual usage. This will be evaluated by comparing patient-reported data to objective measures such as blood test results and documented cannabis levels in medical records. We hypothesize that patients tend to underreport their cannabis use relative to the levels detected through clinical testing.

Following signing an informed consent, study participants will be asked to complete a preoperative questionnaire to assess their cannabis consumption habits.

Prior to anesthesia adminsatration, a 6 cc blood sample will be collected from the patient's intravenous line. This sample will be used to measure cannabis levels in the blood, allowing for a comparison between self-reported cannabis use and actual detected levels. The sample will be immediately labeled with a unique serial number in the operating room. After plasma separation via centrifugation, the sample will be frozen for later analysis using high-performance liquid chromatography (HPLC . All samples will be deidentified to external personal.

Following surgery, participants will be asked to complete questions postoperatively up to 7 days. These follow-ups will gather information on any changes in cannabis use as well as symptoms such as pain intensity, nausea, sleep quality, and use of rescue medications.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients who use cannabis and are scheduled to undergo elective surgery.
  • A matched control cohort of patients with similar demographics who are also scheduled for elective surgery.

Exclusion criteria

None

Treatment and study plan

This study is non interventional and will only include filling in questionnaires and providing blood and urine sample

Other

urine sample

Primary outcomes

  1. discrepancy percentage between reported cannabis users and actual cannabis usage among patients undergoing elective surgery.

    Time frame: up to 7 days

  2. Use of Cannabis

    Time frame: up to 7 days postopertively

    Doasge Use of Cannabis

Secondary outcomes

  1. Pain levels during surgery as assesed using VAS

    Time frame: up to 7 days

    We aim to assess whether pain levels during surgery are affected by cannabis use of the VAS questionaire

Sponsors and collaborators

Lead sponsor

Hadassah Medical Organization

Other

Registry information

Official study title

Perioperative Prospective Follow Up Of Cannabis Consumers

Important dates

Study start
2026
Primary completion
2026
Study completion
2027
First posted
May 12, 2026
Registry last updated
May 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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