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Completed

NCT Number: NCT01726205

Perioperative Pregabalin and Continuous Wound Infusion for Pain Control Following Thoracotomy

The purpose of this study is to assess the efficacy of pregabalin or pregabalin and continuous wound infusion versus placebo for analgesia following thoracotomy

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Key information

Conditions

Post-thoracotomy Pain

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Attikon Hospital

Athens, Greece

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients scheduled for a thoracotomy,

Exclusion criteria

  • age >70 years
  • BMI > 30
  • preoperative Hb < 10 mg/dL
  • preexistent chronic pain
  • neurologic disease
  • chronic assumption of alcohol
  • treatment with analgesics, anxiolytics, sedatives, antidepressants, or calcium channel inhibitors

Treatment and study plan

Pregabalin and normal saline infusion, PRG

Drug

Pregabalin and ropivacaine 02% infusion

Drug

Placebo drug, normal saline infusion

Drug

Primary outcomes

  1. Pain control

    Time frame: 5 days postoperatively

Secondary outcomes

  1. morphine consumption

    Time frame: 3 days postoperatively

Other outcomes

  1. side effects, pain at 1 and 3 months, incidence of neuropathic pain

    Time frame: 3 months

Sponsors and collaborators

Lead sponsor

Attikon Hospital

Other

Registry information

Important dates

Study start
2008
Primary completion
2012
Study completion
2012
First posted
Nov 14, 2012
Registry last updated
Nov 14, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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