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OpenTrials
Completed

NCT Number: NCT05513248

Perioperative Outcomes of Anatomic Lung Resections in Patients Who Recovered From Coronavirus Disease 2019

This study will determine the outcomes of anatomic lung resections in patients who recovered from coronavirus disease 2019 (COVID-19) disease by describing the morbidity and mortality as well as the length of postoperative hospital stay.

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Key information

Conditions

COVID-19 Actinomycetales Infections Bacterial Infections Bacterial Infections and Mycoses Coronaviridae Infections Coronavirus Infections Gram-Positive Bacterial Infections Hemoptysis Hemorrhage Infections Lung Cancer Lung Diseases Lung Neoplasms Lung TB Mycobacterium Infections Neoplasms Neoplasms by Site Nidovirales Infections Pathologic Processes Pathological Conditions, Signs and Symptoms Pneumonia Pneumonia, Viral RNA Virus Infections Respiratory Tract Diseases Respiratory Tract Infections Respiratory Tract Neoplasms Signs and Symptoms Signs and Symptoms, Respiratory Thoracic Neoplasms Tuberculosis Tuberculosis, Pulmonary Virus Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

Lung Center of the Philippines

Quezon City, National Capital Region, 1100, Philippines

About this study

This study will be conducted at the Lung Center of the Philippines. The study design is a retrospective case series implemented via chart review. Online and written patient records will be reviewed to determine the baseline patient characteristics and the preoperative outcomes. Patients who recovered from COVID-19 will be selected from those who underwent anatomic lung resection from June 1, 2020 to May 31, 2022. This study will be done in accordance with the Helsinky Declaration and Good Clinical Practice Guidelines, and will be subject for approval of the institutional Ethics and Technical Review Boards. Descriptive statistics will be used to describe patient characteristics and perioperative outcomes.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • underwent anatomic lung resection
  • previous COVID-19 infection documented by nasopharyngeal swab RT-PCR or GeneXpert
  • with negative nasopharyngeal swab RT-PCR or GeneXpert prior to lung resection

Exclusion criteria

  • with incomplete patient records

Treatment and study plan

anatomic lung resection

Procedure

includes minimally invasive or open lung segmentectomy, lobectomy, bilobectomy and pneumonectomy

Primary outcomes

  1. Mortality rate

    Time frame: perioperative period (up to 30 days after anatomic lung resection)

    proportion of patients who died due to perioperative complications

  2. Major complication rate

    Time frame: perioperative period (up to 30 days after anatomic lung resection)

    proportion of patients who develop acute kidney injury, acute myocardial infarction, acute respiratory distress syndrome (ARDS), acute respiratory failure, atelectasis requiring intervention, bronchopleural fistula, empyema thoracis, hemothorax, pneumonia, stroke or venous thromboembolism

  3. Minor complication rate

    Time frame: perioperative period (within 30 days after anatomic lung resection)

    proportion of patients who develop atrial fibrillation, pneumothorax or prolonged air leak

  4. Length of postoperative hospital stay

    Time frame: perioperative period (up to 30 days after anatomic lung resection)

    time duration from surgery to discharge order

Sponsors and collaborators

Lead sponsor

Lung Center of the Philippines

Other

Registry information

Official study title

Perioperative Outcomes of Anatomic Lung Resections in Patients Who Recovered From Coronavirus Disease 2019 (COVID-19): a Two-Year Retrospective Case Series

Important dates

Study start
2022
Primary completion
2022
Study completion
2022
First posted
Aug 24, 2022
Registry last updated
Nov 9, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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