Skip to main content
OpenTrials
Recruiting

NCT Number: NCT06776640

Perioperative Oral Vitamin D3 Supplementation on Implant Osseointegration

The number of patients treated in Implantology at Nantes University Hospital is 400 per year. This pilot study aims to demonstrate the efficacy of a 6-month oral cholecalciferol supplementation on osseointegration in patients requiring dental implants and presenting with vitamin D deficiency, compared to French patients who have not undergone vitamin D screening

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Implant Site Reaction

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

About this study

This study will be conducted on patients with vitamin D deficiency or insufficiency who visit the Restorative and Surgical Dentistry Department at the Dental Care Center of Nantes University Hospital for implant surgery. The investigator will present the study to them and record their verbal non-opposition. Clinical data from before the surgery (approximately 3 months prior), during the surgery, and postoperative visits up to 3 months afterward will be included in the OSIVID study.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male or female patient ≥ 18 years old, candidate for dental implant placement.
  • with vitamin D deficiency or insufficiency: 25(OH)D < 25 ng/L.
  • affiliated with a social security scheme.

Exclusion criteria

  • with a local contraindication for implant placement.
  • under guardianship, curatorship, or legal protection
  • Pregnant or breastfeeding women

Treatment and study plan

Primary outcomes

  1. The stability of the implan

    Time frame: 3 months (surgery and 3 months after)

    The stability of the implant measured by RFA (Resonance Frequency Analysis)

Study contacts

Contact information is provided by the study sponsor or research team.

Alexandra Poinas, PhD

CONTACT

[email protected]

0253482857

Anne-Gaelle Chaux, MD PhD

CONTACT

[email protected]

02 53 48 28 35

Sponsors and collaborators

Lead sponsor

Nantes University Hospital

Other

Registry information

Official study title

Efficacy of Perioperative Oral Vitamin D3 Supplementation on Implant Osseointegration in Patients With Vitamin D Deficiency

Acronym: OSIVID

Important dates

Study start
2025
Primary completion
2027
Study completion
2027
First posted
Jan 15, 2025
Registry last updated
Jun 24, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.