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OpenTrials
Completed

NCT Number: NCT06189911

Perioperative Blood Transfusion in Open Liver Resection

This observational study is specifically designed to identify the pre-operative risk factors that significantly contribute to perioperative packed red cell transfusions in open liver resection procedures.

The main question it aims to answer are:

1. What are the risk factors of peri-operative blood transfusion in open liver resection procedures 2. What are the difference outcomes between patients who receive blood transfusion and the other group.

Researcher will compare perioperative factor and post operative outcomes between transfused and non-transfused group

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Key information

About this study

After approval of the study protocol from the institutional review board of Chiangmai University (Approval number: ANE-2564-08020), we performed a retrospective review of all patients who underwent an elective open liver resection in our specialized hepato-biliary center from January 2006 through December 2017. This retrospective inquiry comprised 808 patients.

The data was systematically retrieved from electronic medical records. Baseline characteristics including age, gender, body mass index (BMI), co-morbidity, American Society of Anesthesiologists (ASA) classification, diagnosis, hepatitis profile, Child-Pugh classification, cirrhosis, the largest tumor size, previous liver resection, and pre-operative laboratory investigations were collected.

The following intra-operative data were collected: type of liver resection, hilar resection, vascular reconstruction, volume and type of fluid administration, estimated blood loss, packed red cell and blood product transfusion, and operation time. The definitions of liver resection and the type of hepatectomy were aligned with the anatomic classification of the Brisbane 2000 Terminology

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All genders age above 18 year old who underwent open liver resection from 2006-2017
  • Elective open liver resection

Exclusion criteria

  • Patients who death during the course of a surgical operation

Treatment and study plan

Open liver resection

Procedure

The definitions of liver resection and the type of hepatectomy were aligned with the anatomic classification of the Brisbane 2000 Terminology

Primary outcomes

  1. the pre-operative risk factors of perioperative packed red cell transfusions in open liver resection procedures.

    Time frame: the transfusion of packed red cells during the operation and 48 hours after surgery

    Significant risk factors for perioperative blood transfusion were determined by factors with a p-value < 0.05 derived from the multivariable logistic regression analysis. This analysis facilitated adjustments for potential confounders to identify the independent risk factors associated with perioperative blood transfusion

Sponsors and collaborators

Lead sponsor

Chiang Mai University

Other

Registry information

Official study title

The Risk Factors for Perioperative Blood Transfusion in Open Liver Resection, a Retrospective Cohort Study Development of a Transfusion Scoring System to Predict the Requirement for Perioperative Blood Transfusion in Open Liver Resection

Important dates

Study start
2006
Primary completion
2021
Study completion
2023
First posted
Jan 5, 2024
Registry last updated
Mar 1, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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