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OpenTrials
Completed

NCT Number: NCT04248608

Perioperative Analgesic Modalities for Breast Cancer Surgeries

The incidence of breast cancer is among women world wide, detection increased with introduction of mammography as a screening tool. surgical resection of breast cancer contributes to the generation of acute and chronic post mastectomy pain. This study aims at comparing the effect of erector spinae block versus serratus block versus intravenous morphine in patients undergoing modified radical mastectomy for breast cancer surgeries regarding pain control and possible side effects

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Key information

Conditions

Analgesia Agnosia Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Pathological Conditions, Signs and Symptoms Perceptual Disorders Signs and Symptoms

Age range

18 year–65 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Department of anesthesia and pain medicine. National Cancer Institute

Cairo, 11796, Egypt

About this study

One of the most common types of cancer affecting women is breast cancer. Surgical resection is one of the main approaches applied for solid tumors. surgical approach for breast cancer involve the breast region. Various analgesic modalities are used for proper perioperative pain control. Morphine has always been considered as the gold standard analgesic, however opioids have multiple side effects. Several loco-regional techniques have been introduced for breast surgery pain management including serratus plane block (SPB) and erector spinae plane (ESP) block. In this study the investigators are comparing the effect of erector spinae block versus serratus block versus intravenous morphine in patients undergoing modified radical mastectomy for breast cancer surgeries regarding intraoperative and postoperative analgesia, time to first analgesic, any possible side effects

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • female 18-65 years old patients undergoing modified radical mastectomy

Exclusion criteria

  • patient refusal, local infection at site of block coagulation defect abnormal kidney or liver functions

Treatment and study plan

serratus plane block

Procedure

ultrasound guided block

Other names: SAPB

erector spinae block

Procedure

ultrasound guided block

Other names: ESPB

Morphine sulfate

Drug

intravenous morphine sulfate 0.1 mg/kg

Other names: opioid

Primary outcomes

  1. Visual analogue score

    Time frame: 24 hours

    minimum score (0), maximum score (10) maximum score (10)

  2. Total morphine consumption

    Time frame: 24 hours

    total morphine in mg received in first 24 hours postoprative

  3. First time to receive morphine

    Time frame: 24 hours

    first time to receive morphine in the postoperative period (first 24 hours)

Secondary outcomes

  1. mean arterial blood pressure

    Time frame: 24 hours

    hemodynamic parameters

  2. heart rate

    Time frame: 24 hours

    hemodynamic parameters

Sponsors and collaborators

Lead sponsor

National Cancer Institute, Egypt

Other

Registry information

Important dates

Study start
2020
Primary completion
2020
Study completion
2020
First posted
Jan 30, 2020
Registry last updated
Jul 21, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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