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NCT Number: NCT06857331

Perioperative Analgesia With Erector Spinae Plane Block in Liver Transplant Recipients

The goal of this clinical trial is to learn if ESP block is safe and effective for perioperative analgesia in patients undergoing liver transplant. The main question it aims to answer are Is ESP block safe and has a minimum side effects, like hematoma? Is it effective for perioperative analgesia? Researchers will compare the results to a group of patients who underwent liver transplants without any regional anaesthesia techniques.

Participants will receive bilateral thoracic ESP block on the day of the transplantation with a subsequent bilateral catheterization.

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Key information

Conditions

Liver Transplant Erector Spina Plan Block

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Universal Hospital Oberig

Kyiv, Ukraine

Location status: Recruiting

Location contact

Nazarii Mysynchuk

CONTACT

[email protected]

+380731624586

Nazarii Mysynchuk

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • impaired liver function - cirrhosis or chronic liver disease with the development of hypocoagulation (APTT > 35 sec, INR > 1.5), thrombocytopenia, patients requiring major abdominal surgery, age > 18 years, written consent to participate in the study was obtained

Exclusion criteria

  • Platelet count <50x109, failed ESP catheterization unilateral or bilateral, failed epidural anesthesia attempt, history of allergy or hypersensitivity to local anesthetics, hepatopulmonary syndrome, patients on mechanical ventilation before surgery, patients on CRRT before surgery, refusal to participate in the study

Treatment and study plan

Erector Spinae Plane Block using 0.2% ropivacaine

Procedure

Bilateral thoracic ESP block on the day of the transplantation with a subsequent catheterization will be suggested for the patients. In case of their written consent for the participation in the study this procedure will be performed on the day of the operation. 0.2% ropivacaine is going to be used throughout all the perioperative period.

Primary outcomes

  1. Pain reduction postoperative

    Time frame: from enrollment to the 2nd postoperative day

    Pain assessment with scores

  2. Opioid reduction intraoperatively

    Time frame: from enrollment to the end of the operation

    The amount of intraoperative fentanyl

  3. Need for opioids postoperatively

    Time frame: from enrollment to the 2nd postoperative day

    Need for opioids postoperatively

Study contacts

Contact information is provided by the study sponsor or research team.

Nazarii Mysynchuk

CONTACT

[email protected]

+380731624586

Sponsors and collaborators

Lead sponsor

Bogomolets National Medical University

Other

Registry information

Official study title

Optimization of Perioperative Analgesia With Erector Spinae Plane Block During Major Abdominal Surgeries in Patients With Impaired Liver Function

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Mar 4, 2025
Registry last updated
Mar 4, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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