Skip to main content
OpenTrials
Completed

NCT Number: NCT07165054

Periodontal Pathogens and Atherom Plaque The Number of Mitochondrial DNA Copies

Periodontitis is a chronic inflammatory disease of the tooth-supporting tissues characterized by the constant interaction of microorganisms in subgingival plaque and host defense mechanisms. Periodontitis is considered a focus of infection caused by oral bacteria, bacterial byproducts, or inflammatory mediators that can interact with other parts of the body via the bloodstream.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Periodontal Inflammation Biofilm Endothelial Dysfunction Oral Bacteria

Age range

25 year–90 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Health Sciences University, Hamidiye Faculty of Dentistry, Department of Periodontology

Istanbul, Turkey (Türkiye)

About this study

Periodontitis is a chronic inflammatory disease of the tooth-supporting tissues characterized by the constant interaction of microorganisms in subgingival plaque and host defense mechanisms. Periodontitis is considered a focus of infection caused by oral bacteria, bacterial byproducts, or inflammatory mediators that can interact with other parts of the body via the bloodstream.

Periodontal bacteria produce endotoxins in the form of lipopolysaccharide (LPS). Circulating LPS reacts with Toll-like receptors, promoting the production of reactive oxygen species and phagocytosis in the intima layer. Oxidative stress has been reported to be associated with mtDNA copy number.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosed with endarterectomy
  • Not receiving chemotherapy
  • Not having received this treatment before

Exclusion criteria

  • Having systemic infection
  • Patients with severe heart disease

Treatment and study plan

atheroma plaque

Other

Before the endarterectomy procedure, samples will be collected for study from some of the atheroma plaques routinely taken for pathology from patients.

dental plaque

Other

Subgingival plaque samples will be collected from patients before the endarterectomy procedure.

Primary outcomes

  1. Bacterial frequency (%)

    Time frame: Months 6-9 of the study

    The percentage of bacteria in the red complex in atheroma plaque and dental plaque is evaluated using polymerase chain reaction methods.

Secondary outcomes

  1. Changes in mtDNA copy number (number)

    Time frame: Months 6-9 of the study

    Evaluation by means of quantitative polymerase chain reaction of mtDNA copy number in atheroma plaque

  2. periodontal healths (mm)

    Time frame: 8 months

    Evaluation by means of periodontal indices such as PI, GI, BOP, PD.

Sponsors and collaborators

Lead sponsor

Istanbul Saglik Bilimleri University

Other

Registry information

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Sep 10, 2025
Registry last updated
Jan 30, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.