Periodontal Microbiota in Systemic Sclerosis

Inclusion criteria

Common inclusion criteria

• Men or women over 18 (adults)
• Affiliation to a social health insurance plan
• Subject able to understand the aims and risks of the research and to give signed informed consent form prior to the inclusion in the study
• More than 12 teeth suitable for evaluation

Inclusion criteria

for systemic sclerosis patients

• Systemic sclerosis patient with a diagnosis based on the American College of Rheumatology/European League Against Rheumatism criteria (LeRoy et al., 1988 ; van den Hoogen et al., 2013)
• Diagnosis made during the 2 years preceding study inclusion (early form of the disease)

Inclusion criteria

for controls

• Patient attending the Oral Medicine and Surgery Department from the University Hospital of Strasbourg for a routine dental consultation

Exclusion criteria

• - Subject under court protection
• Subject under guardianship or curatorship
• Pregnancy or breastfeeding
• Impossibility to provide accurate information (emergency situation, comprehension difficulties…)
• Subject currently involved in another clinical trial or in an exclusion period following participation in another clinical trial
• Smoking (≥ 10 cigarettes per day)
• Other associated systemic auto-immune disease (Sjögren syndrome with positive serum anti-SSA and/or anti-SSB auto-antibodies, systemic lupus erythematosus…)
• Progressive chronic illness other than systemic sclerosis
• Acute infection at inclusion
• Progressive cancer or cancer diagnosed within 2 years prior to the study
• Ongoing antibiotic and/or antifungal treatment or within 3 months prior to inclusion
• Probiotics and/or prebiotics intake within 3 months prior to inclusion
• Oral antiseptics within the week before inclusion (chlorhexidin mouthwashes…)
• Risk of infective endocarditis
• Corticosteroids ≥10 mg/day and/or proton pump inhibitors within 3 months prior to inclusion
• Previous hematopoietic stem cell transplantation
• Another cause of skin sclerosis (radiotherapy of the orofacial area…)
• Periodontal specialized treatments, root and/or periodontal surgical treatment and/or subgingival instrumentation within the year before inclusion