Perifollicular Doppler in Natural Cycle In Vitro Fertilization

Perifollicular Doppler could reflect the quality of the follicle's vascularization and, consequently, the one of the oocyte that ensues from it. Perifollicuar Doppler is the analysis, in ultrasound, of the blood flow in vessels surrounding the follicle.

The goal of this study is to evaluate if there is a link, in natural cycle In Vitro Fertilization, between the quality of the vascularization and the one of the oocyte, the embryo and the pregnancy.

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Key information

Conditions

Infertility Genital Diseases Urogenital Diseases

Age range

18 year–38 year

Sex eligibility

Female

Study type

Observational

Primary location

Ovo Fertilité

Montreal, Quebec, H4P 2S4, Canada

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patient with a natural In Vitro Fertilization cycle.
Patient under 38 years old
Body mass indice under 35
Ovulatory cycles between 20-35 days

Exclusion criteria

Patient with a stimulation In Vitro Fertilization cycle
Patient with a naturalIn Vitro Fertilization cycle with egg donor
Patient with a natural In Vitro Fertilization cycle with freezing embryo
Smoking patient
Diabetic patient
Patient with treatment of antihypertensive drug, anticoagulant, antiplatelet, vasodilator
Body mass indice over 35
Patient over 38 years old
Patient without ovulation or cycle over 35 days
Percutaneous Epididymal Sperm Aspiration (PESA), Testicular Sperm Extraction (TESE) or micro TESE

Treatment and study plan

Doppler ultrasound

Procedure

Doppler Ultrasound

Primary outcomes

Quality perifollicular doppler and quality of the oocyte

Time frame: 2 weeks

The measurements are done twice; on days of induction and oocyte retrieval. During the blood sample collection on the day of the induction, there is also a measurement of progesterone, estradiol and luteinizing hormone (LH).

Sponsors and collaborators

Lead sponsor

Clinique Ovo

Industry

Registry information

Important dates

Study start: 2012
Primary completion: 2013
First posted: Aug 20, 2012
Registry last updated: Jun 24, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed