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NCT Number: NCT07747441

Perfusion Index and Spinal Hypotension in Day-Case Knee Arthroscopy

This prospective observational study aims to investigate the role of the baseline perfusion index (PI) in predicting spinal anesthesia-induced hypotension (SAIH) in ASA I-II patients undergoing day-case knee arthroscopy.

Spinal anesthesia is a widely preferred technique for lower extremity surgeries, including knee arthroscopy. However, sympathetic blockade during spinal anesthesia frequently leads to significant hemodynamic instability, particularly hypotension, which can result in adverse perioperative outcomes. While age and baseline blood pressure are traditional risk factors, they often fail to accurately predict the onset of hypotension in healthy populations. The perfusion index (PI), a non-invasive parameter measured via pulse oximetry, reflects peripheral vascular tone and baseline sympathetic activity. An elevated baseline PI indicates baseline vasodilation and a higher susceptibility to sympathectomy, potentially offering an early and non-invasive prediction of SAIH before the hemodynamic collapse occurs.

The primary outcome of the study is the incidence of spinal anesthesia-induced hypotension (defined as a mean arterial pressure < 65 mmHg or a decrease in systolic blood pressure > 25% from baseline). Secondary outcomes include the onset time of sensory block, and intraoperative ephedrine and fluid requirements.

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Key information

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Ankara Etlik City Hospital

Ankara, Yenimahalle\Ankara, 06170, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Between the ages of 18-65
  • Having an ASA Score of I-II
  • Including data collection of parts that underwent knee arthroscopy

Exclusion criteria

  • Patients under 18 and over 65 years of age
  • Patients with ASA Score III and above

Treatment and study plan

Primary outcomes

  1. Spinal anesthesia-induced hypotension

    Time frame: During the surgery

    Defined as a mean arterial pressure < 65 mmHg or a decrease in systolic blood pressure > 25% from baseline

Secondary outcomes

  1. Investigation of Sensory Block Kinetics

    Time frame: Periprocedural

    Time to reach the T10 sensory dermatome

  2. Vasopressor Consumption

    Time frame: During the surgery

    Total amount of rescue vasopressor (Ephedrine) consumed to treat hypotension during the intraoperative period

Study contacts

Contact information is provided by the study sponsor or research team.

Musa Ass. Prof Zengin, Ass. Prof

CONTACT

[email protected]

05071302750

İbrahim MD Topcu, MD

CONTACT

[email protected]

05437860316

Sponsors and collaborators

Lead sponsor

Ankara Etlik City Hospital

Other Gov

Registry information

Official study title

Predictive Value of Baseline Perfusion Index for Spinal Anesthesia-Induced Hypotension in Healthy Patients Undergoing Knee Arthroscopy: A Prospective Observational Trial

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Aug 5, 2026
Registry last updated
Aug 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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