Perfusion Enhancement With Respiratory Impedance in Stroke (PERI-Stroke)

Inclusion criteria

• Age > 18 years
• Ability and willingness to sign informed consent by patient or legally acceptable surrogate decision maker
• Acute ischemic stroke within 72 hours of study enrollment
• Imaging or examination confirming unilateral frontal lobe involvement in the stroke

Exclusion criteria

• Hemorrhagic conversion of ischemic infarct
• History or presence of congestive heart failure, as defined by any of the following:

• Any preceding diagnosis of congestive heart failure as per patient report or medical record
• Report of moderate or severe systolic or diastolic dysfunction on prior
• Reduced ejection fraction, <50%, on prior echocardiogram
• Jugular venous pulsations >10 cm
• Pulmonary edema on chest radiography Of note, an echocardiogram is not required prior to study enrollment.
• History or presence of cardiomyopathy, as per medical record, patient report, or prior echocardiogram
• History or presence of pneumothorax or hemothorax
• History or presence of COPD
• History of current use of home oxygen
• Presence of pneumonia, as clinically determined by the primary medical team after admission chest radiography
• Age < 18 years
• Skull defect that would interfere with CBF monitoring
• Pregnancy (urine or serum testing will required prior to enrollment of any pre-menopausal women)
• Structural brain lesion, including known primary tumor, metastatic tumor, or vascular malformation
• Prior neurosurgical procedure
• Any medical condition that the clinical investigator feels would pose a hazard to the subject if he/she participated in the study