Skip to main content
OpenTrials
Recruiting

NCT Number: NCT06024837

Performance of Spectral CT-scan in Patients With Metastatic Colorectal Cancer: a Prospective Multicentre Study

Spectral CT is a rapidly expanding imaging modality that allows a reduction in iodine dose and irradiation compared to conventional scanning. It uses the difference in attenuation of the material according to the two different energy levels of the incident x-ray beams. The dual-energy scanner has a wide range of clinical applications, particularly in abdominal imaging.

Recruiting

Interested in participating?

Request Info

Key information

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU Saint-Etienne

Saint-Etienne, 42000, France

Location status: Recruiting

Location contact

Rémi GRANGE, MD

CONTACT

[email protected]

(0)477828963 ext. +33

Rémi Grange, MD

PRINCIPAL_INVESTIGATOR

Sylvain GRANGE, MD

CONTACT

[email protected]

(0)477829066 ext. +33

Sylvain Grange, MD

SUB_INVESTIGATOR

About this study

First of all, the virtual creation of mono-energy images between 40 and 140 keV has shown subjective and objective improvement of tumor detection of hypovascular lesions using low energies (40keV). It has been shown to be of interest in vascular and cardiac imaging, and to reduce artefacts in bone imaging. However, its performance in oncology analysis has been little studied. The selection of patients for peritoneal and hepatic carcinosis surgery is fundamental, as surgery allows a prolongation of survival, but are associated with a non-negligible morbi-mortality rate.

Spectral CT provides improved detection of peritoneal carcinosis and liver metastases of colorectal cancer compared to conventional CT acquisition.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients followed for colorectal cancer with synchronous or metachronous liver metastases and/or peritoneal carcinosis
  • Patients with a curative surgical resection plan

Exclusion criteria

  • Patients with non-metastatic colorectal cancer
  • Patients treated with chemotherapy without surgical plans
  • Patients with colorectal cancer with extra-hepatic and extra-peritoneal metastases alone (e.g. lung, bone)

Treatment and study plan

CT Images

Other

Analysis of CT images of peritoneal and/or liver metastases from colorectal cancer

Primary outcomes

  1. Comparison of peritoneal lesion mapping between spectral scanning and conventional scanning

    Time frame: Year : 1

    Comparison of peritoneal lesion mapping between spectral scanning (monoenergetic acquisitions, iodine mapping, etc.) and conventional scanning (acquisition obtained during spectral acquisition).

  2. Comparison of hepatic lesion mapping between spectral scanning and conventional scanning

    Time frame: Year : 1

    Comparison of hepatic lesion mapping between spectral scanning (monoenergetic acquisitions, iodine mapping, etc.) and conventional scanning (acquisition obtained during spectral acquisition).

Secondary outcomes

  1. Evaluation of response to chemotherapy in RECIST 1.1

    Time frame: Year : 1

    Collection of demographic, biological and surgical data.

  2. Evaluation of response to chemotherapy in Radiomics

    Time frame: Year : 1

    Collection of demographic, biological and surgical data.

Study contacts

Contact information is provided by the study sponsor or research team.

Rémi GRANGE, MD

CONTACT

[email protected]

(0)477828963 ext. +33

Sylvain GRANGE, MD

CONTACT

[email protected]

(0)477829066 ext. +33

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Saint Etienne

Other

Registry information

Important dates

Study start
2023
Primary completion
2025
Study completion
2025
First posted
Sep 6, 2023
Registry last updated
Sep 20, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.