PERformance of Multi-Cancer Early-detectIon Based on Various Biomarkers in fEmale BREAST Cancers, PERCEIVE-BREAST

Inclusion criteria

for All Participants:

• Able to provide a written informed consent.
• Female, at least 18 years old.

Additional Inclusion Criteria for Breast Cancer Participants:

• Pathologically confirmed breast cancer diagnosis or highly suspicious for breast cancer within 42 days prior to blood draw.
• No prior cancer treatment before the blood draw.

Additional Inclusion Criteria for Breast Benign Disease Participants:

• Pathologically confirmed breast cancer diagnosis or highly suspicious of breast benign diseases within 90 days prior to blood draw.
• No prior radical treatment before the blood draw.

Exclusion criteria

for All Participants:

• During pregnancy or lactation.
• Recipient of organ transplant or prior non-autologous (allogeneic) bone marrow or stem cell transplant.
• Recipient of blood transfusion within 7 days prior to blood draw.
• Recipient of anti-tumor drugs to treat non-cancer diseases prior to blood draw, such as rheumatic drugs (methotrexate, cyclophosphamide, or azathioprine), or endocrine drugs (tamoxifen).

Additional Exclusion Criteria for Breast Cancer Participants:

• Multiple primary tumors.