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Completed

NCT Number: NCT06545240

Performance of Mid-Upper Arm Circumference for Detection of Severe Acute Malnutrition in Indonesian Under-Fives

WHO recommends 11.5 cm as a cut-off point of Mid-Upper Arm Circumference (MUAC) to detect and/or diagnose severe acute malnutrition (SAM) in under-five. MUAC is practical and useful, especially in area with limited facilities which has no standardized scale and infantometer. However, several studies showed that this cut-off need to be evaluated as it has modest detection rate for SAM. This study aims to evaluate diagnostic value of MUAC with 11.5 cm cut-off compared to WHZ as gold standard to identify SAM. The sensitivity, specificity, positive and negative predictive value of MUAC with 11.5 cm as a standard cut-off will be evaluated.

This study also aim to find new cut-off value that may offer better diagnostic performance. The main research questions were:

What is the diagnostic accuracy of Mid-Upper Arm Circumference (MUAC) compared to the Weight for Height Z Score (WHZ) in identifying SAM in children, and what is the optimal MUAC cut-off value for enhanced diagnostic performance?

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Key information

Conditions

Severe Acute Malnutrition Hypersensitivity Immune System Diseases Malnutrition Nutrition Disorders Nutritional and Metabolic Diseases

Age range

6 month–59 month

Sex eligibility

All sexes

Study type

Observational

Primary location

Puskesmas Cengkareng, Jakarta, DKI Jakarta, Indonesia

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Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • under-fives that 6-59 months-old

Exclusion criteria

  • ascites
  • edema
  • hydrocephalus
  • tumor or oncologic diseases
  • organomegaly
  • uncooperative during measurement

Treatment and study plan

Mid-upper arm circumference

Diagnostic Test

Mid-upper arm circumference was taken using non-stretchable band SECA 202

Other names: Weight measurement, Length and height measurement

Primary outcomes

  1. Diagnostic value of MUAC in diagnosing SAM compare to WHZ-index

    Time frame: 2 months

    To evaluate sensitivity, specificity, positive and negative predictive value of MUAC

Secondary outcomes

  1. Finding new cut off value that offer better diagnostic performance using ROC

    Time frame: 2 months

    To compare sensitivity, specificity, positive and negative predictive value of MUAC with 11.5 cm as standard cut off and to new cut-off value that may offer better diagnostic performance

Sponsors and collaborators

Lead sponsor

Indonesia University

Other

Registry information

Important dates

Study start
2020
Primary completion
2020
Study completion
2020
First posted
Aug 9, 2024
Registry last updated
Aug 9, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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