Skip to main content
OpenTrials
Completed

NCT Number: NCT01633138

Performance-based Reinforcement to Enhance Cognitive Remediation Therapy

The purpose of this study is to investigate whether monetary reinforcement for performance will enhance the effects of cognitive remediation therapy for substance users seeking treatment at an outpatient facility.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Substance-related Disorders Chemically-Induced Disorders Mental Disorders

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Substance Abuse Treatment Unit

New Haven, Connecticut, 06511, United States

About this study

Forty individuals seeking treatment for an alcohol or cocaine use disorder at the Substance Abuse Treatment Unit (SATU) will be randomized to receive cognitive remediation therapy with or without additional compensation based on performance. Participants will use the computerized cognitive remediation program (PSSCogRehab 2012) three times per week for four weeks. The primary outcome measure will be an improved performance on the computerized tasks, with secondary outcomes of changes in cognitive functioning (e.g., attention, concentration, memory) as measured by neuropsychological tests between baseline and post-treatment.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18 to 60 years old
  • Primary Alcohol and/or Cocaine Abuse/Dependence Diagnosis
  • Abstinence from all drugs/alcohol for 30 days
  • Mild cognitive impairment
  • Sufficiently stable and plan to commit to 4 weeks of outpatient treatment
  • Fluent in English and 6th grade reading ability

Exclusion criteria

  • Severe cognitive impairment indicative of dementia
  • Untreated bipolar or psychotic disorder
  • Have current legal case pending such that incarceration during 4-week study is likely

Treatment and study plan

Cognitive Remediation Therapy - Standard

Behavioral

Computerized cognitive remediation therapy provided three times per week for four weeks

Cognitive Remediation Therapy plus Contingency Management

Behavioral

Standard cognitive remediation therapy plus monetary incentives based on performance provided three times per week for four weeks.

Primary outcomes

  1. Improvement in performance scores on computerized cognitive remediation tasks

    Time frame: 4 weeks

    Performance scores on various computerized cognitive remediation tasks will be measured repeatedly during the 4 week study. These scores include "time to completion", "number of errors", "number of words correctly recalled", and "percentage of task completed"

Secondary outcomes

  1. Improved cognitive function on neuropsychological tests

    Time frame: 4 weeks

    Change in cognitive function between baseline and post-treatment will be measured by performance on neuropsychological tests, such as Trail Making Test A & B, Wisconsin Card Sort Test, Digit Symbol Test from WAIS-IV, and the Continuous Performance Test-II (CPT-II).

Sponsors and collaborators

Lead sponsor

Yale University

Other

Collaborators

  • National Institute on Drug Abuse (NIDA)

Registry information

Official study title

Pilot Study of Performance-based Reinforcement to Enhance Cognitive Remediation Therapy for Substance Users

Important dates

Study start
2012
Primary completion
2014
Study completion
2014
First posted
Jul 4, 2012
Registry last updated
Mar 9, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.