Perceval Aortic Bioprostheses : Durability Study.

Exclusion criteria

Perceval bioprosthesis explanted during the same surgical procedure. History of aortic root surgery.

Primary Endpoint :

• Survival free from valve degeneration, according to VARC-3 criteria for structural or non-structural valve dysfunction.

Secondary endpoints :

• Freedom from aortic valve reintervention
• Freedom from SVD
• Freedom from permanent pacemaker implantation
• Freedom from stroke or transient ischemic attack
• Freedom from cardiac related rehospitalization
• Cardiac-specific mortality

Preoperative clinical data are collected via the DxCare electronic medical record system (including weight, height, medical history, and cardiovascular risk factors). Surgical data (type of procedure, operative time, outcomes at the end of surgery) are also extracted from the same software.

Follow-up Procedures :

Included patients are systematically scheduled for a cardiology follow-up consultation as part of routine annual postoperative care at the university hospital or in private practice. During this visit, they undergo a transthoracic echocardiography and a clinical assessment of their health status. These data are collected for analysis.

If patients are not followed up at the hospital and are considered lost to follow-up, their referring cardiologist will be contacted to obtain the most recent cardiological health data.

The annual follow-up echocardiography focuses on evaluating the hemodynamic parameters and durability of the bioprosthesis (presence or absence of pathological regurgitation, leaflet immobility, or thickening).

Clinical status is also assessed during the annual follow-up, including symptoms such as dyspnea, chest pain, and limitations in daily activities.

As part of standard follow-up, patients are contacted by phone and informed of the purpose of their scheduled visit to the Montpellier University Hospital.

For patients unable to attend an in-person consultation, a telephone interview is conducted to assess their clinical status, and their cardiologist is contacted to provide the most recent echocardiography report and clinical follow-up data. For patients who died before the beginning of the study, their trusted contact is approached to obtain clinical information regarding their medical history prior to death.

Inclusion criteria

• Patients with severe or non-severe aortic stenosis, symptomatic or asymptomatic, who received a rapidly deployed Perceval aortic bioprosthesis between January 1, 2012, and January 31, 2023, in the cardiac surgery department at Montpellier University Hospital.

Exclusion criteria

• Perceval bioprosthesis explanted during the same surgical procedure.
• History of aortic root surgery.