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NCT Number: NCT05252312

Perception of Nonverbal Acoustic Signals and Resulting Physiological Responses (SINOVE-PER)

Like many other animals, humans produce nonverbal signals including screams, grunts, roars, cries and laughter across a variety of contexts.Due to their acoustic structure, nonverbal vocalizations and valanced speech (e.g., yelling) are also likely to elicit predictable physiological, perceptual or behavioural responses in the receiver of the signal (the listener). This is critical if researchers are to gain a comprehensive understanding of the broad range of mechanisms and the evolved functions of acoustic communication.

Therefore, in this research, investigators will examine specifically how exposure to vocal stimuli affects both the cognitive and biological responses of the listener.

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Key information

Conditions

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU Saint-Etienne

Saint-Etienne, 42055, France

Location status: Recruiting

Location contact

David REBY, MD PHD

SUB_INVESTIGATOR

Nicolas MATHEVON, MD PHD

SUB_INVESTIGATOR

Roland PEYRON, MD PhD

PRINCIPAL_INVESTIGATOR

About this study

Like many other animals, humans produce nonverbal signals including screams, grunts, roars, cries and laughter across a variety of contexts. Many of these signals (such as cries) are already produced at birth and are likely to serve a number of important biological and social functions. In addition, human speech is characterized by nonlinguistic acoustic parameters (such as pitch, formant frequencies, and nonlinear phenomena) that are known to correlate with biologically important traits of the vocalizer.

Due to their acoustic structure, nonverbal vocalizations and valanced speech (e.g., yelling) are also likely to elicit predictable physiological, perceptual or behavioural responses in the receiver of the signal (the listener).

However, while a number of playback studies have examined behavioural responses (e.g., ratings) of listeners when exposed to various voice stimuli, very few studies have examined whether such behavioural responses are accompanied by an underlying physiological response. This is critical if researchers are to gain a comprehensive understanding of the broad range of mechanisms and the evolved functions of acoustic communication.

Therefore, in this research, investigators will examine specifically how exposure to vocal stimuli affects both the cognitive and biological responses of the listener.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Participant should be affiliated or entitled to a social security scheme

Exclusion criteria

  • Pregnancy
  • Hearing impairment, speech production disorders or major health problems.

Treatment and study plan

Psycho-acoustic tests

Behavioral

Listeners' cognitive and biological responses to vocal stimuli will be tested using psycho-acoustic tests. After listening to acoustic stimuli, participants will be asked to judge these stimuli on relevant evaluation criteria (e.g., "how distressed does this person sound?").

These stimuli might be human voices, animal voices or synthetic voices Physiological measures will be simultaneously taken using an array of complimentary, non-invasive techniques such as the Nociception Level (NOL) Index or video pupillometry

Primary outcomes

  1. Proportion of correct responses in a forced-choice task after vocal stimuli

    Time frame: Immediately after the vocal stimuli

    Participants will be asked to judge vocal stimuli Example : "Of the two baby cries you listened to, which one do you think shows the most distress"

  2. Numerical values of judgements along a scale

    Time frame: Immediately after the vocal stimuli

    Participants will be asked to judge vocal stimuli Example : participants may be asked to judge, along a gradient (from 0 to 100), "how consistent the distress of the baby you heard is to you".

  3. Response time (second)

    Time frame: Immediately after the vocal stimuli

    Participants will be asked to judge vocal stimuli In this case, the participant is instructed to respond as soon as possible. The response time for each stimulus is then systematically measured

Secondary outcomes

  1. Heart rate (bpm)

    Time frame: During the vocal stimuli

  2. Skin conductance (Siemens)

    Time frame: During the vocal stimuli

  3. Skin temperature (°C)

    Time frame: During the vocal stimuli

  4. Nociception Level Index (NOL)

    Time frame: During the vocal stimuli

    A non-invasive finger probe, containing four sensors, will be placed on the on the index finger of the participants.

  5. Pupillary diameter (millimeter)

    Time frame: During the vocal stimuli

    Using a high resolution binocular for automated pupil diameter measurement with an infrared camera

Study contacts

Contact information is provided by the study sponsor or research team.

Nicolas MATHEVON, PhD

CONTACT

[email protected]

04 77 48 50 22 ext. +33

ROLAND PEYRON, MDPhD

CONTACT

[email protected]

(0)477127805 ext. +33

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Saint Etienne

Other

Collaborators

  • University of Lyon

Registry information

Official study title

Perception of Nonverbal Acoustic Signals and Resulting Physiological Responses SINOVE-PER

Acronym: SINOVE-PER

Important dates

Study start
2022
Primary completion
2027
Study completion
2027
First posted
Feb 23, 2022
Registry last updated
May 6, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.