Perception of Facial Expressions Following Correction of Wrinkles and Folds

Inclusion criteria

• Signed informed consent
• NLFs assessed as moderate of severe using the WSRS
• Intent to undergo optimal correction of both NLFs
• Intent to undergo correction of at least one other wrinkle or fold in the lower face

Exclusion criteria

• Subject who presents with a severity of wrinkles or folds that require other treatments, e.g. laser treatment, chemical peeling, to achieve optimal correction
• Subject who presents with severe midface volume loss
• Subject who presents with facial hair, e.g. beard, moustache, in the treatment area
• Woman who is pregnant or breast feeding or plans to become pregnant during the study
• Treatment with chemotherapy, immunosuppressive agents, immunomodulatory therapy (e.g. monoclonal antibodies), systemic or topical (facial) corticosteroids (inhaled corticoids are allowed) within three (3) months before study treatment
• Previous surgery, including aesthetic facial surgical therapy, liposuction or tattoo, in the treatment area
• Previous tissue augmenting therapy or contouring with permanent filler or fat-injection below the zygomatic arch
• Previous tissue augmenting therapy, contouring or revitalisation treatment with non-HA filler, e.g. Calcium Hydroxyapatite (CaHa), or Poly L-Lactic Acid (PLLA), below the zygomatic arch within 24 months before treatment
• Previous tissue augmenting therapy, contouring or revitalisation treatment with non-permanent filler below the zygomatic arch within 12 months before treatment
• Previous tissue revitalisation treatment with neurotoxin below the zygomatic arch within six (6) months before treatment
• Previous tissue revitalisation treatment with laser or light, mesotherapy, chemical peeling or dermabrasion below the zygomatic arch within six (6) months before treatment
• Any medical condition that, in the opinion of the treating investigator, would make the subject unsuitable for inclusion (e.g. a chronic, relapsing or hereditary disease that may interfere with the outcome of the study)