Peptide GAM Immunoadsorption Therapy in Autoimmune Membranous Nephropathy

Membranous nephropathy (MN) is among the most common causes of nephrotic syndrome in adults worldwide. The majority of patients will remain stable with either complete remission or partial remission but approximately 20% will progress slowly to end stage renal disease necessitating the need for renal replacement therapy (RRT).

Current standard therapy for primary (or autoimmune) membranous nephropathy is a regime of rotating high dose steroids and immunosuppression was first described in the mid-nineties and has been the mainstay of treatment since but comes with a high side effect burden.

Idiopathic membranous nephropathy is now understood to be an autoimmune disease characterised by the presence of IgG autoantibodies to M-Type Phospholipase A2 Receptor (anti-PLA2R). Immunoadsorption is a method of removing specific circulating immunoglobulins and has been shown to remove over 80% of circulating IgG with a single session immunoadsorption of 2.5 plasma volumes, with albumin and antithrombin III almost unaffected. With multiple sessions this can rise to over 98%.

Immunoadsorption therapy has been in use for a number of years and this study will use Peptide GAM Immunoadsorption therapy developed by Fresenius Healthcare. This uses two systems, the Art Universal and ADAsorb. The Art Universal became commercially available in 2005 and the ADAsorb in 2002.

Inclusion criteria

• Biopsy confirmed Primary Membranous Nephropathy within the last 3 years
• Active disease despite 6 months of supportive care including ACEi or ARB (Active disease defined as uPCR > 300mg/mmol or 24 hour urinary protein >3.5g/1.73m2)
• Disease severity that in the physicians view warrants treatment prior to completion of 6 months supportive care
• Anti-PLA2R titre > 170 u/ml
• Haemophilus and Pneumococcal vaccinations up to date
• Above the age of 18
• Able to provide informed consent

Exclusion criteria

• Evidence of causes of secondary membranous nephropathy
• eGFR < 20ml/min
• Treatment with steroids or immunosuppression (including but not limited to cyclophosphamide, MMF or azathioprine) and Biologics (including but limited to Rituximab or belimumab) within 6 months of screening
• Therapeutic Plasma Exchange within 28 days of screening
• Previous renal transplantation
• Co-morbidity, which in physicians' view, would preclude patient from treatment with immunoadsorption.
• Pregnant at time of screening