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NCT Number: NCT05874362

People Bereaved by Violent Death : Negative Event Biases and Temporal Perception

A violent death is defined by its brutality, unexpectedness and is secondary to an external cause (suicide, homicide, accident). Bereavement following a violent death constitutes a particular clinical situation, at risk of complications. Research on bereavement after a violent death shows higher risks of psychiatric and somatic complications than in bereavement by non-violent death. These complications, sometimes comorbid, take the form of depressive episodes, post-traumatic stress disorders, suicidal behavior and prolonged grief disorders after 12 months, precociously mediated by ruminations.

Processes responsible for this increased risk of complications are poorly documented. Current literature relates mainly to socio-demographic and epidemiological factors which, alone, do not explain this difference in risks. Further research is needed exploring other kinds of data and processes. To our knowledge, there is no description of early neurocognitive functioning in people bereaved after violent death. This study aims at exploring early neurocognitive processes which can lead to complications in people bereaved by violent death.

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Key information

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

About this study

This work is based on cognitive models of post-traumatic stress disorder involving cognitive biases as factors of development and maintenance of symptomatology. Indeed, in people exposed to a potentially traumatic event, it has been found that an early deterioration in cognitive functioning is a risk factor for developing post-traumatic stress disorders . Among these cognitive alterations, attentional biases toward threat are the most explored and research shows both facilitated engagement and difficulties in disengagement in front of threatening stimuli. In addition, while expecting for a negative event, there is changes in the perception of time . These processes can be explored on a behavioral level and in electroencephalography , in particular through the evoked related potentials following a stimulus. Among these evoked related potentials , the Late Positive Potential component reflects the attentional process, while the Contingent Negative Variation component and the α and β power reflects temporal perception.

As exposure to violent death can have a traumatic impact, our hypothesis is that people bereaved by violent death could present attentional biases, and that these biases would be prodromal of the onset of a psychiatric disorder (Post-traumatic stress disorders , depression afterwards). The objective of this study is to describe the presence of these biases through electrophysiological and behavioral measures in a sample of subjects bereaved by violent death.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • An age between 18 and 65 years old
  • Recent bereavement by violent death of a relative in first and second degree

Exclusion criteria

  • Protected adults
  • Lack of mastering French language
  • History of neurodegenerative disorder
  • History of psychiatric disorder treated pharmacologically with modification of the basic treatment in the month preceding the death
  • The take of an benzodiazepine treatment in the 24th hours before the first visit (T0)

Treatment and study plan

Diagnosis of depressive episode or post traumatic stress disorder

Other

Clinical diagnosis of depressive episode or post traumatic stress disorder, confirmed

No diagnosis of depressive episode or post traumatic stress disorder

Other

No elements in clinical assessment for the diagnosis of a depressive episode or post traumatic stress disorder

Primary outcomes

  1. Amplitude of the Late Positive Potential (LPP) component in unpredictable event condition

    Time frame: Between Day15 and Day30 after the death of one's loved one

    Measure in Electroencephalography (EEG) of the Late Positive Potential (LPP), an Event Related Potential (ERP) relating to attention biases

Secondary outcomes

  1. Amplitude of the Contingent Negative Variation (CNV ) component in unpredictable event condition

    Time frame: Between Day15 and Day30 after the death of one's loved one

    Measure in Electroencephalography (EEG) of the Contingent Negative Variation (CNV), EEG measures relating to temporal perception

  2. Amplitude of the alpha and beta power in unpredictable event condition

    Time frame: Between Day15 and Day30 after the death of one's loved one

    Measure in Electroencephalography (EEG) of the alpha and beta power, EEG measures relating to temporal perception

  3. Comparison of Constant Errors (CE) relative to time estimates in the unpredictability condition (D15-J30) in people developing a psychiatric complication at 3 months and in people not developing these complications.

    Time frame: Between Day15 and Day30 after the death of one's loved one

    Proportion of overestimation of the duration preceding an unpredictable event, and calculation of the point of subjective equality, for measurements of constant errors (CEs) corresponding to the difference between the effective time and the point of subjective equality for each subject

Study contacts

Contact information is provided by the study sponsor or research team.

Laurene LESTIENNE

CONTACT

[email protected]

0033437915120

Véronique VIAL

CONTACT

[email protected]

0033437915522

Sponsors and collaborators

Lead sponsor

Hôpital le Vinatier

Other

Registry information

Official study title

People Bereaved by Violent Death : a Negative Event Biases and Temporal Perception Study

Acronym: PrEVENT

Important dates

Study start
2023
Primary completion
2026
Study completion
2026
First posted
May 24, 2023
Registry last updated
Jun 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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