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OpenTrials
Completed

NCT Number: NCT05744908

Pentosan Polysulfate Treatment's Effectiveness

To examine the relationship between symptoms and quality of life before and after oral pentosan polysulfate (PPS) treatment in cases diagnosed with interstitial cystitis/painful bladder syndrome (IC/BPS).

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Key information

Conditions

Chronic Interstitial Cystitis Cystitis Cystitis, Interstitial Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Male Urogenital Diseases Urinary Bladder Diseases Urogenital Diseases Urologic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Basri Cakiroglu, Istanbul, Turkey (Türkiye)

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About this study

Demographic characteristics, medical history, clinical conditions, and laboratory and cystoscopic data of patients who applied to our clinic between January 2018 and December 2021 and were diagnosed with IC/BPS were retrospectively analyzed. Adult male and female patients with IC/BPS who received 300 mg/day PPS at least six months ago with complaints of pain, urge, frequency, and nocturia not associated with urinary tract infection were included in the study. In addition, pre- and post-treatment symptoms, ICSI scores, quality of life (scored between 1-4), and satisfaction were compared.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Chronic interstitial cystitis
  • Bladder Pain Syndrome

Exclusion criteria

  • Acute cystitis
  • Bladder cancer
  • Chronic prostatitis
  • Bladder stone
  • Stress incontinence

Treatment and study plan

Pentosan Polysulphate

Other

300mg 3 times a day

Primary outcomes

  1. bladder wall thickness

    Time frame: Three months

    0.3 over 3 mm 1 under 3 mm,

  2. improvement of lower urinary tract symptoms

    Time frame: Three months

    1 if symptoms improved, 0 if not

Sponsors and collaborators

Lead sponsor

Hisar Intercontinental Hospital

Other

Registry information

Official study title

Retrospective Evaluation of the Effectiveness of Oral Pentosan Polysulfate Treatment in the Improvement of Chronic Interstitial Cystitis Symptoms

Important dates

Study start
2018
Primary completion
2021
Study completion
2023
First posted
Feb 27, 2023
Registry last updated
May 22, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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